O ne of the main aims of neuroscience is to understand how the CNS deals with and adapts to external inputs and internal events. The altered molecular and cellular events form a basis for abnormal processing that underlies physiopathological events. Understanding these events can allow translation from bench science to the patient, and a key step in this process is using models of a clinical co...

There is no doubt that children suffer from limb pains more than adults. Since the most obvious difference between the child and the adult is the process of growth, it is hardly surprising that these pains have been dubbed 'growing pains'. An immediate objection is that the pains occur most commonly when growth is far from rapid: the years from 8 to 12, when the pains are most common, form, in ...

There is no doubt that children suffer from limb pains more than adults. Since the most obvious difference between the child and the adult is the process of growth, it is hardly surprising that these pains have been dubbed 'growing pains'. An immediate objection is that the pains occur most commonly when growth is far from rapid: the years from 8 to 12, when the pains are most common, form, in ...

Outside the groves of academe few people today read George Crabbe's trenchant rhymed couplets describing the life and landscape of his native Suffolk in the late eighteenth and early nineteenth centuries. This is a pity because Crabbe is a real original: an unpoetical poet who believed that it was his duty to instruct his readers as accurately as possible about the painful realities ofhuman lif...

Growing pains are the most common form of recurrent musculoskeletal pains in childhood and are present in 10-20% of children, mainly between the ages of 3-12 years. The diagnosis is based on typical historical clinical characteristics with a normal physical examination. The etiology is still unknown but current theories include low pain thresholds, as in fibromyalgia and local overuse pain that...

MUSCLE pains have been reported as occurring after the administration of suxamethonium chloride. Bourne et al. (1952) made passing mention of this, but not until 1954 did Churchill-Davidson fully describe these pains and determine their incidence — primarily in the ambulant patient. His series was small, covering 68 patients. In view of considerable speculation on the frequency and importance o...