HYPOTHESIS Multiple organ dysfunction (MOD) within 48 hours of injury is a reversible physiologic response to tissue injury and resuscitation. DESIGN A prospective 10-year inception cohort study ending September 2003. SETTING Regional academic level I trauma center. PATIENTS One thousand two hundred seventy-seven consecutive trauma patients at risk for postinjury multiple organ failure (M...

PURPOSE OF REVIEW Severe trauma is associated with hemorrhage, coagulopathy and transfusion of blood and blood products, all associated with considerable mortality and morbidity. The aim of this review is to focus on resuscitation, transfusion strategies and the management of bleeding in trauma as well as to emphasize on why coagulation has to be monitored closely and to discuss the rationale o...

BACKGROUND Transfusion of packed red blood cells (PRBCs) is associated with an increased incidence of nosocomial infections and an increased risk of death. The duration of storage before transfusion may influence these outcomes. Here, we explore the association between the age of transfused PRBCs and specific patterns of inflammatory gene expression in severely injured trauma patients. METHOD...

INTRODUCTION We tested two hypotheses that disseminated intravascular coagulation (DIC) and acute coagulopathy of trauma-shock (ACOTS) in the early phase of trauma are similar disease entities and that the DIC score on admission can be used to predict the prognosis of patients with coagulopathy of trauma. METHODS We conducted a retrospective study of 562 trauma patients, including 338 patient...

Current Opinion in Critical Care 2009, 15:527–535 Purpose of review To bring together in one review article, the most current and relevant evidence relating to military trauma resuscitation. Recent findings The main themes highlighted by this review are coagulopathy of trauma shock (CoTS), damage control resuscitation, haemostatic resuscitation, the management of massive transfusion, use of adj...

conclusions due to more sophisticated diagnostic tools and surgical approaches, mortality and morbidity of blunt aortic injuries were significantly reduced over the years compared to thoracic endovascular aortic repair and or over two different time periods. objectives the aim of the present study was to retrospectively evaluate the mortality and morbidity with either treatment option. therefor...

Objective: Transfusion-related acute lung injury (TRALI) is a relatively uncommon complication in patients who undergo plasma-containing blood product transfusion. Despite the cross matching process, TRALI remains the most common cause of mortality associated with transfusion. We describe a case of TRALI in a 24year-old trauma patient who was successfully cared for on extracorporeal membrane ox...

Massive bleeding in trauma patients is a serious challenge for all clinicians, and an interdisciplinary diagnostic and therapeutic approach is warranted within a limited time frame. Massive transfusion usually is defined as the transfusion of more than 10 units of packed red blood cells (RBCs) within 24 h or a corresponding blood loss of more than 1- to 1.5-fold of the body's entire blood volum...

Introduction Trauma is one of the leading causes of mortality worldwide, resulting in a great global burden of disability and mortality [1,2]. Approximately half of all trauma deaths occur during the first hours due to traumatic brain injury or massive bleeding. Later deaths are due to, for example, sepsis or multiple organ failure [3]. Independent risk factors for post-injury sepsis are still ...

objective: to record and classify mechanisms of injury and injury severity score (iss) in trauma patients admitted to the largest trauma center in southern iran. methods: this was a prospective cross-sectional study including all the patients who were admitted to nemazee hospital from 2009 to 2010. we recorded the trauma injury information of 1217 patients who were admitted to of emergency room...