نتایج جستجو برای: shbg
تعداد نتایج: 1178 فیلتر نتایج به سال:
The liver produces plasma sex hormone-binding globulin (SHBG), which transports sex steroids and regulates their access to tissues. In overweight children and adults, low plasma SHBG levels are a biomarker of the metabolic syndrome and its associated pathologies. Here, we showed in transgenic mice and HepG2 hepatoblastoma cells that monosaccharides (glucose and fructose) reduce human SHBG produ...
BACKGROUND The new Elecsys chemiluminescence assay for measurement of homodimeric sex hormone-binding globulin (SHBG) was designed for use with undiluted serum, in contrast to other methods that require predilution. During assay development, unexpected calibration difficulties were observed that were attributable to particular biochemical properties of the highly concentrated SHBG in solution. ...
OBJECTIVE Reduced sex hormone-binding globulin (SHBG) concentration predicts insulin resistance and type 2 diabetes, but its association with cardiovascular disease (CVD) risk is unclear. We examined the association between SHBG and cardiovascular risk factors, independently of total testosterone (TT), in young men. DESIGN Observational, cross-sectional study. SETTING General community. P...
Submit Manuscript | http://medcraveonline.com in SHBG levels when compared between those with MetS and without (P =0.8). On univariate and multivariate analysis for obese men, both TT and SHBG remained significantly and independently lower in obese men with MetS, for TT (OR 6.4 CI (-321.9-157.9) P< 0.00001), and for SHBG (OR 1.39, CI (-49.3-19.6) P= 0.00001). In men with no MetS, both TT and SH...
سابقه و هدف : حدود 40 درصد زندگی زنان در دوره ی بعد از یائسگی قرار دارد. سندرم متابولیک یک مشکل مراقبت بهداشتی مهمی است. بر اساس گزارشی از ایران شیوع این بیماری در زنان یائسه، بالا می باشد. تا کنون مطالعه جداگانه ای برای بررسی ارتباط بین هورمون های جنسی زنان یائسه با سندرم متابولیک انجام نشده است. در این مطالعه ارتباط بین هورمون استرادیول، هورمون تستوسترون، shbg، fei و fti را با افزایش خطر سندر...
Plasma sex hormone-binding globulin (SHBG) regulates the access of androgens and estrogens to their target tissues and cell types. An SHBG homologue, known as the androgen-binding protein, is expressed in Sertoli cells of many mammalians, but testicular expression of human SHBG is restricted to germ cells. The primary structure of SHBG comprises tandem laminin G-like (LG) domains. The amino-ter...
Metabolic syndrome (MetS) is a strong risk factor for type 2 diabetes and cardiovascular disease. Conditions associated with hyperandrogenism are often associated with glucose intolerance and other features of MetS in young women. As the prevalence of MetS increases with age and is probably multifactorial, it is reasonable to hypothesize that age-related changes in androgens and other hormones ...
BACKGROUND Low total testosterone (TT) and sex hormone-binding globulin (SHBG) concentrations have been associated with the metabolic syndrome (MetS) in men, but the reported strength of association varies considerably. OBJECTIVES We aimed to investigate whether associations differ across specific subgroups (according to age and body mass index (BMI)) and individual MetS components. DATA SO...
To investigate a potential causal role of natural variation in endogenous testosterone levels the development acne, we performed two-sample sex-stratified Mendelian randomisation (MR) study. Instrumental variables comprised genetic variants with genome-wide significant effects on total (TT), free (FT) and steroid hormone binding globulin (SHBG) male female participants UK Biobank. The these ins...
Transl Androl Urol, Vol 3, Suppl 1 September 2014 www.amepc.org/tau © Translational Andrology and Urology. All rights reserved. followed up in 2013. ED was estimated by the score of the five-item international index of erectile dysfunction (IIEF-5). TT, SHBG, E2, FSH, LH were gauged with precise instrument. FT, BT were calculated by Vermeulen’s formula. Results: A total of 651 Chinese healthy m...
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