Severe infection with respiratory syncytial virus (RSV) during infancy is strongly associated with the development of asthma. To identify genetic variation that contributes to asthma following severe RSV bronchiolitis during infancy, we sequenced the coding exons of 131 asthma candidate genes in 182 European and African American children with severe RSV bronchiolitis in infancy using anonymous ...

BACKGROUND An imbalance in the generation of pro-inflammatory leukotrienes, and counter-regulatory lipoxins is present in severe asthma. We measured leukotriene B4 (LTB4), and lipoxin A4 (LXA4) production by alveolar macrophages (AMs) and studied the impact of corticosteroids. METHODS AMs obtained by fiberoptic bronchoscopy from 14 non-asthmatics, 12 non-severe and 11 severe asthmatics were s...

Asthma currently affects an estimated 300 million people worldwide and the number is expected to rise to 400 million by 2025. Asthma morbidity remains high and the economic burden is significant. Approximately 20% of patients have severe persistent asthma. As patients with severe asthma often have a variety of conditions that may coexist with or be mistaken for asthma, careful diagnosis and man...

Abstract Due to the increased number of patients suffering from asthma, mechanism this disease has been subject much attention public and finding a cure for is urgent. A changed abundance microbiome proven play an important role in genesis development asthma. In study, function were studied. It was found that there significant changes components when asthma mild severe. This study could help us...

Statistically, more than 50% of people with moderate to severe asthma also have chronic sinusitis indicating a direct connection between sinusitis and asthma; many studies show the connection between sinus infections and asthma [3]. One 2006 study showed that when compared with those who only have asthma, people who have both sinusitis and asthma tend to have more severe asthma symptoms, may ha...

Background. The control of severe bronchial asthma, such as corticosteroid-resistant asthma, is difficult. It is also possible that immunosuppressive agents would be effective for bronchial asthma. Case Summary. A 55-year-old Japanese female presented with severe bronchial asthma controlled with tacrolimus. She had been diagnosed with bronchial asthma during childhood. Her asthma worsened, and ...

BackgroundRespiratory infections in infancy are associated with the development of allergic asthma and atopy. Delineating whether symptomatic a marker atopic predisposition or contribute to is important for preventive strategies. We hypothesized that early, severe lower respiratory tract (LRTIs) may be risk factor disease.ObjectiveOur aim was determine clinically defined, moderate-to-severe LRT...

Coexistence of chronic rhinosinusitis (CRS) with asthma appears to impair asthma control. Type-2 innate lymphoid cells (ILC2s) respond to the cytokines of thymic stromal lymphopoietin (TSLP), interleukin (IL)-25 and IL-33, thus contributing to airway diseases such as CRS and asthma. We investigate whether the augmented Th2-cytokines in CRS might be related to sinonasal tract ILC2s corresponding...

_Background:_ Asthma is an airway disorder where inflammatory cytokines are partly responsible for exacerbating the disease. Interleukin (IL)-32, generally referred to as natural killer cell (NK4) transcript 4, described immunoregulator involved in stimulation of anti-/pro-inflammatory cytokines. The abnormal presence IL-32 has been observed during diseases, particularly asthma. This study aims...