Background. Klotho and fibroblast growth factor 23 (FGF23) are key regulators of mineral metabolism in renal insufficiency. FGF23 levels have been shown to increase early in chronic kidney disease (CKD); however, the corresponding soluble Klotho levels at the different CKD stages are not known. Methods. Soluble Klotho, FGF23, parathyroid hormone (PTH), 1,25-dihydroxy vitamin D3 (1,25D) and othe...

purpose: to investigate the levels of klotho and endothelin-1(et-1) in plasma and aqueous humor in patients with pseudoexfoliation syndrome (pes). methods: fifteen individuals with pes and 15 age-matched subjects without pes who were scheduled for cataract extraction participated in the study. samples of aqueous humor and peripheral blood were taken in the operating room just before cataract su...

Klotho is a renal protein involved in phosphate homeostasis, which is downregulated in renal disease. It has long been considered an antiaging factor. Two Klotho gene transcripts are thought to encode membrane-bound and secreted Klotho. Indeed, soluble Klotho is detectable in bodily fluids, but the relative contributions of Klotho secretion and of membrane-bound Klotho shedding are unknown. Rec...

Disturbed calcium (Ca(2+)) homeostasis, which is implicit to the aging phenotype of klotho-deficient mice, has been attributed to altered vitamin D metabolism, but alternative possibilities exist. We hypothesized that failed tubular Ca(2+) absorption is primary, which causes increased urinary Ca(2+) excretion, leading to elevated 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] and its sequelae. He...

Chronic kidney disease has an indirect effect on global disorder and death by raising the risks of morbidityand mortality . This study included (60) patient diagnosed chronic renal failure; it also (25)healthy subjects as control In population age ranged from (14-65 years) old who visited Al-BasrahTeaching Hospital in Basrah throughout period October 2020 to February 2021. Enzyme-LinkedImmunoso...

Purpose: To investigate the mechanism of resveratrol protection against sepsis-induced acute kidney injury in mice.
 Methods: A model was established mice by cecal ligation and puncture (CLP). Sixty healthy male ICR were randomly divided into sham operation (sham) group, (CLP) CLP + low-dose (20 mg/kg) treatment (CLP ResL) high-dose (40 ResH) group Klotho (0.01 Klotho) group. All administe...

On the model of premature aging induced by 30-day dark deprivation (light-dark cycle 24/0 h, artificial illumination 300 Lux), effect exogenous melatonin (0.3 mg/kg, 14 days after cancellation deprivation, intragastric dailyin 2 % starch mucus) on dynamics body weight and level Klotho protein in blood was studied outbred white male rats 4 months age. It has been shown that prolonged is accompan...

Klotho is a membrane protein participating in the inhibitory effect of FGF23 on the formation of 1,25-dihydroxyvitamin-D(3) [1,25(OH)(2)D(3)]. It participates in the regulation of renal tubular phosphate reabsorption and stimulates renal tubular Ca(2+) reabsorption. Klotho hypomorphic mice (klotho(hm)) suffer from severe growth deficit, rapid aging, and early death, events largely reversed by a...

BACKGROUND Klotho, as a new anti-aging gene, can shed into circulation and act as a multi-functional humoral factor that influences multiple biological processes. Recently, published studies suggest that klotho can also serve as a potential tumor suppressor. The aim of this study is to investigate the effects and possible mechanisms of action of klotho in human lung cancer cell line A549. MET...