Coenzyme Q 10 is a natural antioxidant and free radicals scavenger. In the present study, we examined effect of coenzyme Q 10 on hemoglobin A 1C , serum urea and creatinine in alloxan-induced Type 1 diabetic rats. Thirty Sprage-Dawley male rats were divided into three groups randomly; group one as control, group two diabetic untreatment, and group three treatments with coenzyme Q ...

Objective- To evaluate the some serum biochemical alterations after urinary diversion with colonic segment.Design- Experimental in vivo study.Animals- five adult healthy mixed breed dogs of both sexes weighing between 25-40 kg. Procedures- In this approach, fifteen centimeters of the descending colon with preservation of its mesenteric vessels was resected and this segment longitudinally was op...

Feline lower urinary tract diseases are known to be life threatening conditions in cats, especially when they occur as obstructive diseases in males. Early diagnosis and treatment is necessary, otherwise it may lead to death. A 3-year-old male Persian cat was referred to the clinic with a history of anuria, lethargy, loss of appetite and exploratory cystotomy 6 months ago due to urethral obstru...

The effect of orally administered sun ginseng (SG), which is a ginseng processed by steaming, was examined in adenine-induced chronic renal failure rat. SG significantly decreased both blood urea nitrogen and serum creatinine levels, indicating an improvement of renal function. Also, SG significantly increased the urinary excretion of both urea and creatinine. Furthermore it lowered the blood p...

Objective: The present study was undertaken to evaluate the aqueous extract of K. pinnata for its protective effects on gentamicin-induced nephrotoxicity in rats. Materials and Methods: Nephrotoxicity was induced in Wistar rats by intraperitoneal administration of gentamicin 100 mg/kg/day for eight days. Effect of concurrent administration of K. pinnata leaf extract at a dose of 125 mg/kg/day g...

Although mammalian urinary tract epithelium (urothelium) is generally considered impermeable to water and solutes, recent data suggest that urine constituents may be reabsorbed during urinary tract transit and storage. To study water and solute transport across the urothelium in an in vivo rat model, we instilled urine (obtained during various rat hydration conditions) into isolated in situ rat...

In this study, the contrast-induced-nephropathy (CIN) of vascular patients who had undergone angiography was quantitatively evaluated using a semi-empirical model. The model compiled six essential serum readings and biological data from 70 patients in order to develop a 1st-order nonlinear equation with 16 defined terms. The expectation value of the model was used to predict the serum creatinin...

The renin-angiotensin-aldosterone system (RAAS) plays a key role in diabetic nephropathy (DN). Angiotensin-II secreted during the RAAS pathway increases nephropathy. It stimulates oxidative stress which can quench nitric oxide. Reduced oxide level aggravates Ang-II-induced vasoconstriction. Ang-II has also emerged as central mediator of glomerular hemodynamic changes that are associated with re...

Hemiscorpius lepturus is medically important scorpion species present in the south and southwest part of Iran, causing morbidity and mortality in children and adults. Unlike other scorpions studied so far, the venom of H. lepturus is highly cytotoxic, that can be a reason for its complexity in clinical manifestations in patients stung by this scorpion. Scarce studies showed the mechanism invol...

BACKGROUND/AIMS Subclinical hypovolemia may contribute to allograft dysfunction in long-term kidney transplant (KT) patients. In order to predict responsiveness to saline hydration, indices for tubular transport were investigated. METHODS Fifty-four clinically euvolemic long-term KT patients with recently aggravated azotemia were given intravenous hydration as follows: 0.9% saline 5 ml/kg ove...