Biofilms pose a serious problem for public health. Penetration of pharmacological agents within a biofilm is hampered by the morphological structure of such microbial communities. A biofilm infection therefore entails adverse outcomes both in the field of cost management and patient prognosis. The problem is further complicated if the drugs available to combat a biofilm-related fungal infection...

Bacterial meningitis is the most common and serious bacterial infection of the central nervous system (CNS), characterized by an acute purulent infection of the piamater, arachnoid and subarachnoid space1. Approximately 1.2 million cases are estimated to occur annually world-wide, resulting in 135,000 deaths2,3. Streptococcus pneumoniae and Neisseria meningitidis are the main etiologic agents r...

background: compounds present in both green and black teas have been shown to inhibit the growth and activity of bacteria associated with mouth infections. the aim of this study was to assess the effects of green tea leaves extract on the aerobic mouth bacterial load. methods: a total of 25 volunteer female students, aged 20-25 years, were selected and then evaluated by green tea extract and mo...

just regarding different risk factors for antibiotic resistant uropathogenes, it seems justice to improve diagnostic power for drug resistant uropathogenes and well appropriate empirical therapy. 300 and 145 cases of clinicopathologically diagnosed nosocomial and spinal cord injured (sci) associated urinary tract infection (uti), respectively, were considered as our samples included in our 24 m...

Gram-negative bacterial infections, especially multidrug-resistant (MDR) bacterial infection, are becoming a serious threat to public health. Although it is widely accepted that both appropriate initial empirical therapy and targeted therapy are important, but for patients needing therapy adjustment, few studies have explored whether adjustment strategy based on microbiologic susceptibility tes...

Obesity is a risk factor for developing severe disease following influenza virus infection; however, the comorbidity of obesity and secondary bacterial infection, a serious complication of influenza virus infections, is unknown. To fill this gap in knowledge, lean and obese C57BL/6 mice were infected with a nonlethal dose of influenza virus followed by a nonlethal dose of Streptococcus pneumoni...

See related articles, p 87 and 94The evaluation management of the febrile young infant is commonly performed in outpatient setting. The subset those aged less than 8 weeks age has traditionally been demarcated from relatively older children by a variety unique clinical factors affecting risk for serious bacterial infection (SBI). These include inadequately developed host defenses, difficulty ac...

To assess the multiple risk factors reported to be associated with onset of serious bacterial, fungal, viral, and protozoal infections in renal allograft recipients, a retrospective study of all renal transplantations performed at Yale-New Haven Medical Center from the inception of the transplantation program in December, 1967, to December, 1975, was undertaken. Ninety-six renal allograft trans...