The relationship between selenium and signal molecules has not been well elucidated. It was found that physiological concentration of selenite, 3 microM, reduced ASK1 activity and induced PI3-kinase (PI3-K)/Akt pathways in HT1080 cells. Duration of these signal molecules by selenite was much longer than that by growth factors and other stresses. The longer duration time of these signal molecule...

BACKGROUND Previous studies demonstrated that selenite induced cancer-cell apoptosis through multiple mechanisms; however, effects of selenite on microtubules in leukemic cells have not been demonstrated. METHODS The toxic effect of selenite on leukemic HL60 cells was performed with cell counting kit 8. Selenite effects on cell cycle distribution and apoptosis induction were determined by flo...

A single subcutaneous dose of 30 nmol of sodium selenite per gram of body weight in 13-day-old rats resulted in posterior subcapsular cataract (PSC) after 24 hr and bilateral nuclear cataracts at 72-96 hr. Within 24 hr of treatment, a 60% decrease in lens glutathione was seen. A loss of calcium homeostasis observed by 48 hr resulted in increased lens calcium (4 mumol/g dry weight), which accomp...

This trial describes the effect of intraruminal infusion of sodium selenite on the in-sacco rumen degradability of a legume, Centrosema pubescens and a grass, Pennisetum purpereum in West African dwarf (WAD) sheep. A total of sixteen WAD sheep of an average body weight, 16.19 ± 2.63 kg were used for this study. A 4 x 4 Latin square design of four sheep and four sodium selenite treatments (doses...

In a recent issue of the Journal, Taylor et al. (1) argued that selenium appears to play an important role not only in preventing various cancers but also in some degenerative diseases. Most of the data on the cancer prevention and cancer reduction effects of selenium are derived from epidemiologic studies (2). However, despite strong evidence for the importance of selenium in carcinogenesis, v...

This article presents the results of therapeutic efficacy in application sodium selenite antioxidant drug and sorbent additive montmorillonite their influence on nonspecific resistance reproductive functions cows. The prevalence gynecological diseases farm, including retention afterbirths non-infectious origin, with relative well-being conditions feeding housing, was reason for search methods p...

The present study describes the effectiveness of removal of selected aqueous anions by several metalloligs, i.e., metal derivatives of a commercially available immobilized ligand, IMLIG, Octolig. This material consists of polyethylenediamine moieties covalently bound to a high-surface area silica gel (CAS Registry number = 404899-06-5). The metals involved are copper, cobalt, iron, nickel, mang...

Sodium selenite and sodium selenate are approved inorganic Se (selenium) compounds in human and animal nutrition serving as precursors for selenoprotein synthesis. In recent years, numerous additional biological effects over and above their functions in selenoproteins have been reported. For greater insight into these effects, our present study examined the influence of selenite and selenate on...

The effects of selenium exposure were studied in LNCaP human prostate cancer cells, and this same cell line adapted to selenium over 6 months to compare acute versus chronic effects of sodium selenite, the latter most closely resembling human clinical trials on the effects of selenium in cancer prevention and therapy. Our results demonstrated that oxidative stress was induced by sodium selenite...