BACKGROUND Rasagiline and selegiline are classified as monoamine oxidase B (MAO-B) inhibitors. The present investigation deals with time-dependent electrical frequency changes (electropharmacograms) induced by these, as well as by aminoindan, the major metabolite of rasagiline. METHOD Adult rats (day-night converted, >5 months old) were fitted with 4 bipolar concentric steel electrodes connec...

The anticonvulsant activity of inhibitors of monoamine oxidase (MAO) was reported early after the development of irreversible MAO inhibitors such as tranylcypromine, but was never clinically used because of the adverse effects of these compounds. The more recently developed reversible MAO inhibitors with selectivity for either the MAO-A or MAO-B isoenzyme forms have not been studied extensively...

Hypothalamic-Adenohypophyseal Disorders • Selegiline Treatment of Canine Pituitary‐Dependent Hyperadrenocorticism • Selegiline Effects on Responses to Medetomidine, Oxymorphone, or Butorphanol in Dogs • Double Pituitary Adenoma Associated With Diabetes Mellitus and Hyperadrenocorticism • Effects of Budesonide on Hypothalamic‐ Pituitary‐Adrenal Axis in Dogs Tests of Thyroid Function • Thyroid Ho...

According to the catecholaldehyde hypothesis, the toxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde (DOPAL) contributes to the loss of nigrostriatal dopaminergic neurons in Parkinson's disease. Monoamine oxidase-A (MAO-A) catalyzes the conversion of intraneuronal dopamine to DOPAL and may serve as a therapeutic target. The "cheese effect"-paroxysmal hypertension evoked by tyramine-conta...

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a gradual decline in memory associated with shrinkage of brain tissue, with localized loss of neurons mainly in the hippocampus and basal forebrain, with diminished level of central cholinergic neurotransmitter-acetylcholine and also reported to be associated with accumulation of ubiquitinated proteins in neur...

BACKGROUND Selegiline, a therapeutic drug for Parkinson's disease (PD), structurally resembles the endogenous parkinsonism-related compound 1,2,3,4-tetrahydroisoquinoline (TIQ). In the present study, we evaluated the effects of 3-methyl-TIQ (3-MeTIQ) and 3-methyl-N-propargyl-TIQ (3-Me-N-proTIQ), selegiline mimetic TIQ derivatives, for preventing 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPT...

usually centres on improving dopaminergic func tion in the nigro-striatal pathways. Levo-dopa and selegiline increase the amount of synaptic dopamine available; apomorphine, bromocriptlne and pergolide are agonists at dopamine receptors. Symptoms may also be improved by redressing the balance of dopaminergic and cholinergic activity. Benzhexol, procyclidine and orphenadrine, among others, are a...