OBJECTIVES To examine the risk of atrial fibrillation or flutter associated with use of non-selective non-steroidal anti-inflammatory drugs (NSAIDs) or selective cyclo-oxygenase (COX) 2 inhibitors. DESIGN Population based case-control study using data from medical databases. SETTING Northern Denmark (population 1.7 million). PARTICIPANTS 32 602 patients with a first inpatient or outpatien...

PURPOSE Selective cyclooxygenase-2 (COX-2) inhibitors may suppress carcinogenesis by both COX-2-dependent and COX-2-independent mechanisms. The primary purpose of this study was to evaluate whether celecoxib or rofecoxib, two widely used selective COX-2 inhibitors, possess COX-2-independent antitumor activity. EXPERIMENTAL DESIGN PC3 and LNCaP human prostate cancer cell lines were used to inv...

Preterm delivery is the leading cause of neonatal mortality and contributes significantly to infant morbidity. Classical cyclooxygenase (COX) inhibitors, such as indomethacin, which inhibit both COX-1 and COX-2, are effective for delaying premature labor, but their use is limited by serious complications to the fetus and neonate, including adverse effects on the ductus arteriosus (DA). Using is...

Nonsteroidal anti-inflammatory drug (NSAID)-sensitivity is a frequent condition in patients with chronic urticaria and/or asthma. The physiopatologic process underlying respiratory and cutaneous reactions probably involves an increased production of cysteinyl leukotrienes. Cyclooxygenase 2 (COX-2) selective inhibitor, has been proposed as the main alternative to control pain and inflammatory di...

Takahashi, Yasushi, Christine Roman, Sylvain Chemtob, Mary M. Tse, Emil Lin, Michael A. Heymann, and Ronald I. Clyman. Cyclooxygenase-2 inhibitors constrict the fetal lamb ductus arteriosus both in vitro and in vivo. Am J Physiol Regulatory Integrative Comp Physiol 278: R1496– R1505, 2000.—Nonselective cyclooxygenase (COX) inhibitors are potent tocolytic agents; however, they also have adverse ...

Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used therapeutic agents. With the introduction of the selective cyclooxygenase-2 (COX-2) inhibitors, the use of this category of medications has expanded; however, the appropriate place for these agents in the therapeutic armamentarium is yet to be defined. Selective COX-2 inhibitors are effective in treating both acute a...

Glaucoma is characterized by a loss of retinal ganglion cells (RGC) which is associated with a decrease of visual function. Neuroprotective agents as a new therapeutic strategy could prevent the remaining neurons from apoptotic cell death. Previous studies have shown the involvement of the Cyclooxygenase (COX)-2 signalling in the apoptotic death of neurons. Herein we investigated the neuroprote...

Nonsteroidal anti-inflammatory drugs (NSAIDs) induce gastrointestinal ulceration as the adverse reaction. This effect of NSAIDs is attributable to endogenous prostaglandin (PG) deficiency caused by inhibition of cyclooxygenase (COX), yet the relation between COX inhibition and the gastrointestinal ulcerogenic property of NSAIDs remains controversial. Using selective COX inhibitors, we examined ...

The role of cyclooxygenase (COX)-1 and -2 in prostanoid formation and modulation of pressor responses to ANG II was investigated in the pulmonary and systemic vascular beds in the rat. In the present study, selective COX-1 and -2 inhibitors attenuated increases in pulmonary arterial pressure and decreases in systemic arterial pressure in response to arachidonic acid but did not alter responses ...