The experiment of Fe-Beta catalysts modified by Ce with incipient wetness impregnation methods was carried out for the selective catalytic reduction NOx NH3. characteristics catalyst before and after hydrothermal treatment were evaluated changes active sites, acid sites pore structure. results showed that conversion from [Fe2+-OX]+ to [HO-Fe3+-OX]+ during reaction aging promoted gradual dehydro...

AIM Oxytocin produces concentration-dependent relaxation of isolated isthmus and ampulla of human oviduct precontracted by histamine. The aim of our study was to investigate whether this oxytocin effect was specific and by which receptors it was mediated. METHODS We investigated effects of oxytocin and its antagonists on isolated isthmus and ampulla of the uterine tubes from 20 women who unde...

Neurokinin A (NKA) induces bronchoconstriction mediated by tachykinin NK(2) receptors in animals and humans, and may be increased in asthma. Because beta(2)-adrenoceptor agonists are the most widely used bronchodilators in asthma, we investigated the effects of the beta(2)-adrenoceptor agonist fenoterol on NK(2) receptor messenger RNA (mRNA) and receptor density as well as the functional respon...

The purpose of the present study was to characterize different beta-adrenoceptors (beta-ARs) and determine their role in the spontaneously tonic smooth muscle of the internal anal sphincter (IAS). The beta-AR subtypes in the opossum IAS were investigated by functional in vitro, radioligand binding, Western blot, and reverse transcription-polymerase chain reaction (RT-PCR) studies. ZD 7114 [(S)-...

In vitro studies were conducted to identify the major metabolites of eplerenone (EP) and the cytochrome p450 (p450) isozymes involved in its primary oxidative metabolism in humans and dogs. The major in vitro metabolites were identified as 6 beta-hydroxy EP and 21-hydroxy EP in both humans and dogs. EP was metabolized by cDNA-expressed human CYP3A4 and dog CYP3A12 but only minimally by human CY...

OBJECTIVE The aim of this study was to determine whether chronic beta-adrenergic receptor (beta-AR) stimulation induces proliferation of human cardiac fibroblasts and to investigate the mechanism(s) involved. METHODS AND RESULTS In vitro cultures of human cardiac fibroblasts were established from biopsies of right atrial appendage. RT-PCR analysis and pharmacological studies demonstrated that...

Both endogenous and exogenous estrogen decrease pulmonary artery (PA) vasoconstriction. Whether these effects are mediated via estrogen receptor (ER)-alpha or ER-beta, and whether the contribution of ERs is stimulus-dependent, remains unknown. We hypothesized that administration of the selective ER-alpha agonist propylpyrazole triol (PPT) and/or the selective ER-beta agonist diarylpropiolnitril...

Pt impregnated on a Sn-beta catalyst results in a very promising catalyst for the selective hydrogenation of α,β-unsaturated aldehydes, compared to the PtSn co-impregnated beta catalysts. Framework tin ions in the Sn-beta sample stabilize the nucleation of platinum nanoparticles inside the zeolite channel. These Pt(0)-Sn(4+) sites, which are only observed in the Pt/Sn-beta catalyst, have been s...

It is known that in rodents and humans the beta 3-adrenergic receptor (beta 3-AR) is present primarily in adipocytes and plays a significant role in the adrenergic stimulation of lipolysis. We examined the expression of beta 3-AR mRNA in the dog and the lipomobilizing effects of beta 3-AR-selective agonists in vivo. Reverse transcription polymerase chain reaction of RNA extracted from dog adipo...

BACKGROUND Testing for the susceptibility of vasodepressor reaction in humans involves the combination of restriction of venous return by passive upright tilting and the administration of isoproterenol. We developed an experimental rat model in which vasodepressor reactions are induced when the inferior vena cava is occluded during an infusion of isoproterenol. The reactions are characterized b...