Purpose: Oxidative stress has recently emerged as a possible mechanism in pathogenesis of epilepsy. Coenzyme Q10 (CoQ10) is a strong endogenous antioxidant that protects cells from lipid oxidation and reactive oxygen species (ROS) production, however, the impact of CoQ10 on seizure characteristics in epileptic patients is not clear. Methods: The current study enrolled patients with the epilept...

objective: to determine the relationship between serum glutathione peroxidase and febrile seizure. materials & methods:   in this case-control study, 43 children with simple febrile seizure (case group) were compared with 43 febrile children without seizure (control group) in terms of serum glutathione peroxidase level. serum glutathione peroxidase levels were measured by elisa method. the resu...

background: febrile convulsion (fc) is one of the most common causes of seizure in children. oral diazepam or oral midazolam are two mostly recommended drugs for fc prevention, but the effectiveness of these drugs remains controversial. prophylactic use of oral anticonvulsant drugs is thus a questionable practice. this study was carried out to compare the effect of using different diazepam dose...

The diagnosis of epilepsy depends upon a number of factors, particularly detailed and accurate seizure history, or semiology. Other diagnostic data, consisting of electroencephalography, video-monitoring of the seizures, and magnetic resonance imaging, are important in any comprehensive epilepsy program, particularly with respect to lateralizing and localizing the seizure focus, if such a focus...

seizure activity has been proposed to result in the generation of reactive oxygen species (ros), which then contribute to seizure-induced neuronal damage and eventually cell death. although the mechanisms of seizure-induced ros generation are unclear, mitochondria and cellular calcium overload have been proposed to have a crucial role. we aim to determine the sources of seizure-induced ros and ...

The seizure EEG records of 25 depressives receiving ECT were 'blindly' rated by two trained raters using a uniform definition of seizure endpoint. The EEG seizure duration estimates were validated against five expected relationships. EEG seizure duration correlated with and was more than motor seizure duration, reduced over the course of ECTs, was consistent within subjects, and negatively vari...

The aim of this study is to investigate the associations between febrile seizure and serum levels of vitamin B12, folic acid, and homocysteine. One hundred and four children who presented with febrile seizure and 75 controls who presented with febrile illness unaccompanied by seizure were enrolled into the study. Mean levels of vitamin B12, folic acid and homocysteine were compared between two ...

In presurgical monitoring, focal seizure onset is visually assessed from intracranial electroencephalogram (EEG), typically based on the selection of channels that show strongest changes in amplitude and frequency. As epileptic dynamics increasingly considered to reflect potentially distributed neural networks, it becomes important also assess interrelationships between channels. We propose a w...

how to cite this article: saeedi borujeni mj, hami j, haghir h, rastin m, sazegargh. evaluation of bax and bcl-2 proteins expression in the rat hippocampus due to childhood febrile seizure. iran j child neurol. winter 2016; 10(1):53-60. abstract objective simple febrile seizure (sfs) is the most common seizure disorder in childhood, and is frequently described as inoffensive disorder. neverthel...