Alzheimer's disease (AD) is characterized by severe neuronal loss as well as the accumulation of amyloid-β (Aβ), which ultimately leads to plaque formation. Although there is now a general agreement that the aggregation of Aβ can be initiated by prion-like seeding, the impact and functional consequences of induced Aβ deposits (Aβ seeding) on neurons still remain open questions. Here, we find th...

Pollen-mediated gene flow in space is well documented and isolation distances are recommended to ensure genetic purity of Brassica napus seed crops. Isolation in time could also contribute to gene flow management but has been little investigated. We assessed the effects of asynchronous and synchronous flowering on intraspecific B. napus gene flow by seeding adjacent plots of transgenic spring c...

Leptomeningeal seeding is a strong negative prognostic factor for medulloblastoma (MB). The mechanism of leptomeningeal seeding is unclear but may involve epigenetic regulation. In this study, we evaluated the feasibility of a histone deacetylase (HDAC) inhibitor, panobinostat, in the suppression of MB leptomeningeal seeding. Panobinostat decreased the cell viability and proliferation, inducing...

Biopsies of liver masses that prove to be hepatocellular carcinomas (HCCs) are associated with a risk of seeding the abdominal or chest wall with tumor cells. The reported frequency of seeding varies greatly in the literature. We performed a retrospective cohort study in a large integrated health care system to examine rates of seeding in patients with HCC who had targeted liver biopsies, ablat...

BACKGROUND Shorter growing season and water stress near wheat maturity are the main factors that presumably limit the yield potential of spring wheat due to late seeding in Saskatchewan, Canada. Advancing seeding dates can be a strategy to help producers mitigate the impact of climate change on spring wheat. It is unknown, however, how early farmers can seed while minimizing the risk of spring ...

This is a report on the progress towards commissioning the hardware for echo-seeding experiments in the FLASH Optical Replica Synthesizer (ORS) section in Jan 2012. It is anticipated that echo-seeding in the ORS section can produce harmonics of the 270 nm seed laser wavelength, generating seeded FEL radiation in the sFLASH undulators with wavelengths ranging from 10 nm to 30 nm. It is planned t...

We proposed an Upstream Multi-Wavelength Shared (UMWS) PON architecture based on a tunable self-seeding Fabry-Perot laser diode (FP-LD) at ONU. The performances of the wavelength and power stability, side-mode suppression ratio (SMSR), tuning range for the proposed tunable self-seeding laser module at ONU are experimentally investigated. The BER is measured with direct modulation on FP-LD of 1....