Anxiety is a normal behavioral component. When it too frequent or appears in inappropriate contexts, can be considered pathological. Benzodiazepines (BDZs) are drugs with clinical success anxiety treatment. BDZs act as allosteric modulators of the γ- aminobutyric acid A receptor (GABAAR). However, these cause adverse effects. Despite therapeutic advances obtained BDZs, search for anxiolytics fe...

Two cases of violent, drug-intoxicated patients who presented considerable problems in management, and were resistant to standard sedative agents, are described. Effective and safe sedation, without the need for full anaesthesia and endotracheal intubation, was achieved using titrated doses of thiopentone. The merits of selecting this agent in these circumstances are discussed.

Patients with borderline personality disorder (BPD) are usually prescribed a variety of psychotropic drugs; however, none is recommended in the guidelines nor has any been approved for this indication. As data on drug prescriptions for BPD are sparse, cross-sectional data from the European Drug Safety Project AMSP were used to analyse drug prescriptions of 2195 in-patients with BPD between 2001...

Abstract Background Older adults are frequently prescribed medications with sedative effects, which associated numerous adverse consequences. However, the use and longitudinal associations of medication in older mild–moderate Alzheimer Disease (AD), has not been explored to date. Methods The association between Sedative Load (SL) events, unscheduled healthcare utilisation, delirium falls over 1...

Despite the large number of elderly patients in nursing homes and the intensity of medication use there, few current data are available on patterns of medication use in this setting. We studied all medication use among 850 residents of 12 representative intermediate-care facilities in Massachusetts. Data on all prescriptions and patterns of actual use were recorded for all patients during one m...

BACKGROUND The rate of severe cutaneous adverse drug reactions is low, and these reactions can result in death or disability. An evidence-based epidemiological study of severe cutaneous adverse drug reactions in China has not been reported. OBJECTIVE The aim of this study was to analyze epidemiology and characteristics of severe cutaneous adverse drug reactions of Chinese inpatients during th...

The role of sedation in patients with acute respiratory failure the intensive care unit is crucial for improving adaptation to mechanical ventilation, avoiding lung injury, and reducing stress related over-stimulated sympathetic tone. drug class alpha 2 agonists, alone or synergic association, can help clinician achieve these goals. Understanding principles pharmacology applying them clonidine ...

anxiety is one of the most common symptoms of mental disorders, significantly affecting work function and interpersonal relationships. its characteristics include a set of cognitive, physical, emotional and behavioral-symptoms. some of these symptoms are: feeling empty heart, shortness of breath, palpitations, flushing, excessive sweating, numbness, dizziness and shaking hands. given the high p...