BACKGROUND & AIMS Patients diagnosed with colorectal cancer (CRC) are at risk for synchronous and metachronous lesions at the time of diagnosis or during follow-up evaluation. We performed a population-based study to evaluate the rate, predictors, and familial risk for synchronous and metachronous CRC in Utah. METHODS All newly diagnosed cases of CRC between 1980 and 2010 were obtained from t...

In 2000, it was estimated that 16,500 new cases of primary brain tumors would occur in the United States, with 13,000 deaths [1]. Although brain tumors constitute only a small proportion (about 1.4 percent) of overall human malignancies, they carry high rates of morbidity and mortality. More terrifyingly, brain tumors often strike young people. Central nervous system neoplasm is the second most...

OBJECTIVES Screening for second primary cancer (SPC) is one of the key components of cancer survivorship care. The aim of the present study was to explore oncologists' experience with promoting second primary cancer screening. METHODS Two focus group interviews were conducted with 12 oncologists of diverse backgrounds. Recurrent issues were identified and placed into thematic categories. RE...

A. SPECIFIC AIMS Women treated with chest radiation for a childhood cancer have a significantly elevated risk of breast cancer at a young age, similar to that of women with a BRCA gene mutation. Because early detection of breast cancer is strongly associated with survival and therapeutic options (radiotherapy, chemotherapy) are limited among these women with previous chest radiation, breast can...

Primary apocrine adenocarcinoma (AA) is a rare malignant cutaneous neoplasm that typically arises in areas of high apocrine gland density such as the axillae and the anogenital region. Due to the nonspecific clinical manifestation of AA, the differential diagnosis may be broad. The rarity of this neoplasm has led to a relative lack of well-established histologic and immunohistochemical diagnost...

Context Solid pseudopapillary neoplasms of the pancreas are extremely rare, accounting for 1-2% of primary pancreatic exocrine tumors and typically occur in women around the second or third decade of life. Tumors occurring in males are exceptionally uncommon. Case report We report herein a case of solid pseudopapillary neoplasm occurring in the pancreatic head in a forty-seven-year-old Hispanic...

Patients with retinoblastoma diagnosed from 1969 to 1980 have been followed up for periods of up to 17 years. Data from a previous study of patients diagnosed from 1962 to 1968 have been included for analysis of incidence and second primary tumours, and for study of trends in treatment. The registration rate in Britain (which may be about 10% less than the true incidence) is about one in 23,000...

BACKGROUND Improving therapies means longer survival for multiple myeloma (MM) patients. We hypothesized that these patients are at an increased risk for a secondary malignancy. OBJECTIVES (i) To investigate the epidemiology and site-specific risk of second primary cancers (SPCs) in patients with MM (ii) To investigate the factors affecting survival in MM patients with SPCs. DESIGN This was...