Summary Background. During the two last decades, the interest in the role of Vitamin D (VD) in allergic disease has increased. Apart from the well-known actions of VD in bone metabolism, recent studies suggested its possible role as an immune-modulator in allergy. Objective. This study, conducted over the Italian territory, evaluated the possible correlations between VD serum level and diagnose...

BACKGROUND Allergies have been associated with decreased risk of glioma; but, associations between duration and timing of allergies, and antihistamine use and glioma risk have been less consistent. The objective was to investigate this association by analyzing types, number, years since diagnosis, and age at diagnosis of allergies, and information on antihistamine usage, including type, duratio...

The prevalence of allergies has vastly increased over recent decades due to air pollution and climate change. The present study aims to identify any seasonal variations in the allergens, to help prevent and treat allergic diseases; and investigate any correlations between the reported allergens and other biotic parameters, namely age and sex. The study included 67 subjects (49 female and 18 mal...

Clinical efficacy and immunological response in children is similar to that of adults after the first treatment season with SQ-standardized grass allergy immunotherapy tablet in two randomized trials Background: Specific immunotherapy is the only treatment of IgE-mediated allergic diseases with the potential to modify the underlying cause of disease and prevent disease progression or even cure ...

Background Despite the efficacy of allergen-specific immunotherapy (AIT), role trained immunity and tolerance in this process has not been elucidated. Objective Here, we have performed a comprehensive longitudinal analysis systemic innate immune cell repertoire during course AIT. Methods Patients with allergy received standard preseasonal subcutaneous AIT allergoids to birch and/or grass. Healt...

Between July 2008 and November 2010, the US Food and Drug Administration (FDA) received 197 consumer reports of prolonged taste disturbances following consumption of pine nuts. Most consumers consistently reported a delayed bitter or metallic taste with foods beginning 4 to 48 hours after pine nut consumption. This bitter taste recurred with any food consumed, lasting on average 5 to 10 days. S...