نتایج جستجو برای: sdf1
تعداد نتایج: 329 فیلتر نتایج به سال:
BACKGROUND AND PURPOSE The initial steps of atherosclerosis and the entry of HIV into the cell share similar biological mechanisms. Therefore, our hypothesis is that the progression of atherosclerosis in patients with HIV infection can be influenced by variations in genes implicated in both processes. METHODS The progression of atherosclerosis over a 2-year follow-up period was measured as th...
Foxc1 mutations have been implicated in Dandy–Walker malformation (DWM), the most common human cerebellar malformation diagnosed by an enlarged posterior fossa and fourth ventricle, and cerebellar hypoplasia. Although loss of this transcription factor causes developmental cerebellar pathology, it is not expressed in the developing cerebellum. Rather it is widely expressed in embryonicmesoderman...
How do migrating neural progenitor cells and growing axons know where to go? In this issue of Neuron, two papers (Knaut et al. and Lieberam et al.) demonstrate that activation of Cxcr4 chemokine receptors by the chemokine SDF1/Cxcl12 can direct both of these tasks.
Vascular growth is necessary for normal lung development. Although endothelial progenitor cells (EPCs) play an important role in vascularization, little is known about EPC function in congenital diaphragmatic hernia (CDH), a severe neonatal condition that is associated with pulmonary hypoplasia. We hypothesized that the function of endothelial colony-forming cells (ECFCs), a type of EPC, is imp...
امروزه استفاده از سلول های بنیادی در سلول درمانی، به عنوان یک استراتژی درمانی نوین در پزشکی ترمیمی، مورد توجه قرار گرفته است. نشان داده شده است که کموکاین sdf1 و گیرنده آن،cxcr4 ، نقش مهمی در مهاجرت، حیات و تکوین چندین نوع سلولی از جمله سلول های بنیادی مزانشیمی بازی می کنند. از این رو می توان با افزایش دادن گیرنده cxcr4 در سطح سلول های بنیادی مزانشیمی، باعث افزایش مهاجرت این سلول ها به بافت صدم...
Type 1 diabetes results from the autoimmune destruction of pancreatic b-cells. Although the disease shows a strong association with HLA class II alleles, other genes may influence the initiation or the rate of progression of the autoimmune process. The recruitment of mononuclear cells within the islets of Langerhans is a critical step in the pathogenesis of the disease. Because chemokines are c...
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