Scytovirin (SVN) is a novel anti-human immunodeWciency virus (HIV) protein isolated from aqueous extracts of the cultured cyanobacterium Scytonema varium. The protein consists of a single 95-amino acid chain with signiWcant internal sequence duplication and 10 cysteines forming Wve intrachain disulWde bonds. A synthetic gene that encodes scytovirin was constructed, and expressed in Escherichia ...

The diazotrophic community in biological soil crusts (biocrusts) is the key supplier of nitrogen dryland. To date, there still limited information on how biocrust development influences succession community, and what are most important factors mediating communities during succession. Using high throughput nifH amplicon sequencing, diazotrophs soils at different developmental stages were compara...

Flagellar class 3 operons of Escherichia coli and Salmonella are transcribed by RNA polymerase containing sigma 28. The consensus sequence of the sigma 28-dependent promoters was believed to be TAAA N15 GCCGATAA. In this study, we found that the E. coli genome contains a large number of sequences homologous to this consensus. However, we showed that they do not always exert a sigma 28-dependent...

A number of recent studies examining historical experiences with deflation have called into question the widely-held view that maintains deflation is economically harmful. These studies contend that a broad, historical perspective reveals a more nuanced view of deflation, one that requires taking seriously both malign and benign deflation. This paper builds on these findings by taking an in-dep...

The need for antineoplastic compounds with novel mechanisms of action is great. One such agent is the recently synthesized polyamine analogue N1-ethyl-N11-((cyclopropyl)methyl)-4,8-diazaundecane (CPENSpm). Exposure of hormone-dependent and -independent human breast cancer cells to 0.1-10 microM CPENSpm led to both growth inhibition and induction of programmed cell death. Fragmentation of DNA to...