Early studies in primary sclerosing cholangitis (PSC) were concerned with disease characterization, and were followed by epidemiological studies of PSC and clinical subsets of PSC as well as a large number of treatment trials. Recently, the molecular pathogenesis and the practical handling of the patients have received increasing attention. In the present review we aim to give an update on the ...

Primary sclerosing cholangitis (PSC) is a fibrosing disease of the intra- and extra-hepatic bile ducts, and is closely associated with inflammatory bowel disease. It is immune mediated, rather than being a classical autoimmune disease. A range of immune abnormalities have been demonstrated in PSC, in particular the findings of a range of autoantibodies, a portal tract infiltrate of functional T...

Primary sclerosing cholangitis (PSC) is an uncommon disorder of unknown etiology, characterized by chronic inflammation and fibrosis of the intra- and extrahepatic bile ducts. PSC is commonly associated with chronic inflammatory bowel disease, especially ulcerative colitis, and often in younger men with an extensive colitis. The diagnosis is made by endoscopic retrograde cholangiography. The ch...

Primary sclerosing cholangitis (PSC) is a generally progressive, sometimes fatal chronic hepatobiliary disorder for which no effective medical therapy now exists. This article describes the epidemiology of this disease, along with diagnosis and treatment options. Future research directions concerning PSC also are discussed.

Autoimmune liver disease is a heterogeneous group of diseases in which the body’s immune cells and antibodies are directed against its own components tissue. The main from this are: autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), sclerosing cholangitis. Most often there classical monovariants disease, but some cases, manifestations two forms observed at once. term “overlap syndro...

ET Cholangiocarcinoma (CCA) is a rare liver cancer that occurs in 1 or 2 individuals per 100,000 in developed regions. Approximately 2500 new cases are diagnosed in the United States each year. The greatest risk factor for developing this cancer is a diagnosis of primary sclerosing cholangitis (PSC). Among patients with this diagnosis, CCA rates may be as high as 30%. Although its overall incid...

PAPER DISCUSSION Background and Study Aims: In a subgroup of patients, primary sclerosing cholangitis (PSC) is complicated by high-grade focal strictures of the bile ducts, and this can have an unfavourable influence on the natural course of the disease. The aim of this

Autoimmunity is regarded as the main mechanism involved in pathogenesis of various liver diseases, such as autoimmune hepatitis (ÁIÇ), primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), autoimmune cholangitis, overlap syndromes AIH-PBC and AIH-PSC and liver dysfunction due to connective tissue diseases. Autoimmune hepatitis is an immune-mediated, autodestructive liver diseas...