The objective of this work is to evaluate the potential effect of cardiac stress exercise on 16 the accumulation of [123I]IAZA, a radiopharmaceutical used to image focal tissue hypoxia, in 17 otherwise normal myocardium in healthy volunteers, and to determine the impact of exercise on 18 [123I]IAZA pharmacokinetics. The underlying goal is to establish a rational basis and a baseline for 19 stud...

introduction: poor sensitivity and poor signal to noise ratio because of low injected thallium dose and presence of scattered photons are the main problems in using thallium in scintigraphic imaging of the heart. scattered photons are the main cause of degrading the contrast and resolution in spect imaging that result in error in quantification. thallium decay is very complicated and photons ar...

Biodistribution, pharmacokinetic, and radioimaging studies were per formed with ""Re-labeled NR-LU-10 whole antibody in athymic nude mice bearing the LS174T tumor growing either s.c. or in an experimental hepatic metastasis model. NR-LU-10 is an IgG2b murine monoclonal antibody (MAb) that reacts with virtually all human tumors of epithelial origin. NR-BC-1, a IgG2b murine MAb that reacts with n...

The formation of an arterial thrombus is a dynamic process that depends upon the characteristics of blood flow, the triggering substrate, and the blood components. We have developed and characterized a sensitive and specific computer-assisted nuclear scintigraphic method to study the dynamics of platelet deposition on severely damaged vessels both in vitro and in vivo in nonstenotic and stenoti...

Many radiopharmaceuticals are applied in the scintigraphic evaluation of inflammatory and infection. The inflammatory reaction represents the reaction of the organism to any traumatic condition and this process atracts leucocytes to the inflamatory focus (chemotaxy) and substances (enzymes, antibodies and complements) that represents the functions of defense and repair, respectively. Labeled le...

A 41-year-old woman was diagnosed with chronic renal disease (CRD) due to interstitial nephropathy secondary to chronic pyelonephritis, arterial hypertension and hyperuricema. She initiated treatment with peritoneal dialysis (PD) in 2007. Four years later she underwent cadaveric kidney transplant in the right iliac fossa requiring transplantectomy 48h later due to venous thrombosis of the graft...

Background: Hairline rib fracture commonly happens after blunt trauma, and it is hard to be detected by X-ray. Many methods can used, among them, the hybrid image of single-photon emission computed tomography (SPECT) (CT) seems produce higher sensitivity for diagnosis. Case presentation: A 63-year-old man came our rehabilitation clinic a vehicle accident 25 days earlier. He had multiple plain f...

OBJECTIVE To correlate myocardial perfusion scintigraphy (MPS) with Tc-99m-MIBI and adenosine infusion using quantitative coronary angiography (QCA) and intravascular ultrasound (IVUS). METHODS Seventy patients with coronary artery disease (CAD) referred for myocardial perfusion scintigraphy (MPS) with MIBI and adenosine were studied. Clinical, electrocardiographic (ECG), and scintigraphic fi...

Background/Aims Gastric motility abnormalities have been considered to be pathophysiological features of functional dyspepsia (FD) that are closely related to dyspepsia symptoms, especially postprandial distress syndrome (PDS). The aims of this study are to (1) investigate the prevalence of gastric motility disorders and (2) evaluate the association between gastric motility abnormalities and dy...

BACKGROUND Lymphoscintigraphy (LS) and sentinel lymph node biopsy (SLNB) have typically been contraindicated for pregnant patients diagnosed with breast cancer because they are considered unsafe. PATIENTS AND METHODS Twenty-six premenopausal non-pregnant patients who were candidates for LS underwent peritumoral injection of approximately 12 MBq of 99mTc-HSA nanocolloids. Static [15 min and 16...