BACKGROUND Sunitinib is a multi-targeted tyrosine kinase inhibitor used in the treatment of advanced renal cell carcinoma (RCC) and imatinib-resistant/intolerant gastrointestinal stromal tumors (GIST). METHODS A meta-analysis of 10 prospective clinical studies in advanced RCC and GIST was performed to support the development of pharmacokinetic (PK) and PK/pharmacodynamic (PD) models that acco...

This paper presents an improved simple power analysis attack against the key schedule of Camellia. While the original attack required an exact determination of the Hamming weight of intermediate data values based on power measurements, in this paper, two variants of the simple power analysis attack are presented and shown to be tolerant of errors that might occur in the Hamming weight determina...

We study methods that improve scheduling robustness under uncertain disturbances and dynamic shop conditions. A new method is proposed based on the notion of preprocessrst-schedule-later by Wu et al. [19]. Preprocessing starts at the beginning of the planning period where we use a Lagrangean Relaxation of the scheduling model to form networkstructured job subproblems. For each job subproblem we...

In this paper we analyze and extend a recently developed “task-swapping” procedure for improving schedules in oversubscribed situations. In such situations, there are tasks which cannot be directly added to the current schedule without introducing capacity conflicts. A schedule is improved if one or more of these tasks can be feasibly included, and the goal of task swapping is to rearrange some...

Reinforcement schedules are considered in relation to applied behavior analysis by examining several recent laboratory experiments with humans and other animals. The experiments are drawn from three areas of contemporary schedule research: behavioral history effects on schedule performance, the role of instructions in schedule performance of humans, and dynamic schedules of reinforcement. All o...

This paper introduces an SPA power attack on the 8-bit implementation of the Twofish block cipher. The attack is able to unequivocally recover the secret key even under substantial amounts of error. An initial algorithm is described using exhaustive search on error free data. An error resistant algorithm is later described. It employs several threshold preprocessing stages followed by a combine...

The construction industry has employed various schedule analysis techniques to support delay claims. Paradoxically, resourcerelated issues are frequently ignored even though they can affect project completion time, too. The research presented here shows that delay analysis without resource allocation practice substantially affects results of schedule analysis. Some delay can cause unrealistic r...

The eight-team Canadian Football League (CFL) features an 18-game regular season played between late June and early November. The regular-season schedule is manually created using an iterative process involving league management, teams, and a television sports broadcaster. We developed a mixed-integer program-driven decision support system that provided league officials with multiple schedule v...