Mutational scanning can be used to probe effects of large numbers point mutations on protein function. Positions affected by mutation are primarily at either buried or exposed residues directly involved in function, hereafter designated as active-site residues. In the absence prior structural information, it has not been easy distinguish between these two categories We curated and analyzed a se...

Sulfur is a key element in terrestrial magmatic processes yet its geochemical behavior remains one of the most difficult to model due heterovalent chemistry. The maximum amount sulfur silicate melt can dissolve before saturating with sulfide (e.g., pyrrhotite) or sulfate anhydrite) changes redox state system and has important implications for budget system. Several empirical models have been de...