Using a modified cell-free culture medium, a mycoplasma was isolated from sarcoid lymph nodes in two cases and from sarcoid skin lesions in four out of seven cases of chronic sarcoidosis. Growth inhibition tests showed that the isolates were related to Mycoplasma orale type 1. By the indirect haemagglutination method, 244 cases of definite or probable sarcoidosis, 160 patients with other diseas...

It is known that smoking affects the development and maintenance of certain types of granulomatous lung diseases. To explore this mechanism(s), we measured tumor necrosis factor (TNF)-alpha concentrations in the culture supernatants of lipopolysaccharide (LPS)-stimulated alveolar macrophages (AMs) in 13 healthy nonsmokers, 13 healthy smokers, 13 nonsmoking sarcoid patients, and 16 smoking sarco...

CONTEXT The sarcoidosis is an idiopathic multisystem inflammatory disease characterized by the presence of non-caseating granulomas in the affected organs. The clinical picture includes non-specific systemic symptoms and organ-specific symptoms, but it is frequently asymptomatic. Although not fully understood, a clear association between sarcoidosis and malignancies has been reported. In neopla...

Because of the possible clinical association between coeliac disease and sarcoidosis, the incidence of humoral sensitivity to dietary proteins was examined in patients with sarcoidosis. Raised concentrations of circulating IgG antibodies to alpha gliadin were found in 41/99 sarcoid patients whereas antibody levels to casein, beta lactoglobulin and ovalbumin were similar to normal controls. Subs...

The concomitant presence of tuberculous and sarcoid like lesions in the lymph nodes, which drain a neoplasm, is very rare. The case which is reported here is that of a 40 years old female patient who presented with a history of a right sided breast mass of 5 years duration. Fine needle aspiration cytology (FNAC) of the breast lump suggested the features of a phyllodes tumour of questionable mal...

BACKGROUND AND OBJECTIVE Sarcoidosis is a systemic granulomatous disorder of unknown aetiology involving multiple organs and often associated with non-granulomatous microangiopathic lesions in various organs. Increased angiogenesis-inducing ability of activated alveolar macrophages was found in bronchoalveolar specimens from patients with pulmonary sarcoidosis and from patients with extrapulmon...

Sarcoidosis (Besnier-Boeck-Schaumann disease) is a multisystem disease of unknown etiology with various cutaneous presentations. It is characterized by the presence of non-caseating ‘naked’ granulomas in the affected tissue. We report a case of polymorphic cutaneous sarcoid in a 39-year-old immunocompetent male. He was visited at our outpatient department with multiple asymptomatic red colored ...

During a ten-year study period, we evaluated 100 histologically-proven sarcoid patients for the development of aspergillomas. Serum precipitins against Aspergillus antigens were used to screen all patients regardless of sarcoid stage. Twelve patients had serum precipitins and were further investigated with tomography and serial serum precipitins testing. Ten of these 12 patients had aspergillom...

To examine whether sarcoid epithelioid cells of granulomatous lesions produce colony-stimulating factor (CSF), a growth factor of monocyte-macrophage series, the primary culture of sarcoid epithelioid cells was carried out from 16 biopsied lymph nodes which contained sarcoid granulomas, CSF activity was demonstrated at high titer in the conditioned media from all the epithelioid cell cultures. ...

The alveolar macrophage (AM) population is widely recognized to be heterogeneous; distinct subpopulations can be identified by the use of macrophage-specific monoclonal antibody (MoAb) probes. We have isolated a macrophage subset that appears to react with both MoAbs that have previously discriminated between dendritic cells and classic macrophages. In the bronchoalveolar lavage (BAL) of patien...