This paper presents a model on the leverage of …nancial intermediaries, where debt are held by risk averse agents and equity by the risk neutral. The paper shows that in an unregulated competitive market, …nancial intermediaries choose to be leveraged over the social best level. This is because the leverage of one intermediary imposes a negative externality upon others by reducing their pro…t m...

One of the important challenges in Graphical models is the problem of dealing with the uncertainties in the problem. Among graphical networks, fuzzy cognitive map is only capable of modeling fuzzy uncertainty and the Bayesian network is only capable of modeling probabilistic uncertainty. In many real issues, we are faced with both fuzzy and probabilistic uncertainties. In these cases, the propo...

The purpose of this study was to assess the possibility of introducing site-specific range margins to replace current generic margins in proton therapy. Further, the goal was to study the potential of reducing margins with current analytical dose calculations methods. For this purpose we investigate the impact of complex patient geometries on the capability of analytical dose calculation algori...

Uncertainties in sediment quality assessments are discussed in five categories: (1) sediment sampling, transport and storage; (2) sediment chemistry; (3) ecotoxicology; (4) benthic community structure; and (5) data uncertainties and QA/QC. Three major exposure routes are considered: whole sediments, and waters in sediment pores and at the sediment-water interface. If these uncertainties are not...

Single-molecule studies can be used to study biological processes directly and in real-time. In particular, the fluorescence energy transfer between reporter dye molecules attached to specific sites on macromolecular complexes can be used to infer distance information. When several measurements are combined, the information can be used to determine the position and conformation of certain domai...