Most studies on new cancer drugs are based on population-derived data, where the absence of response of a small population may pass unnoticed. Thus, individual longitudinal tracking of cells is important for the future development of efficient cancer treatments. We have used digital holographic microscopy to track individual JIMT-1 human breast cancer cells and L929 mouse fibroblast cultivated ...

We examined 66 cats with salinomycin intoxication. Salinomycin caused different LMN signs of varying degrees of severity in all cases. Changes in blood work were unspecific, with the most frequent being increased serum creatine kinase activity, leukocytosis, and increased liver enzymes. Pathological electrodiagnostic findings: fibrillation potentials and positive sharp waves were detected in 10...

The aim of the present studies was to evaluate the effects of salinomycin (Biocox®) on the piglet and growing-fattening pig performance. Forty-eight piglets and 40 growing pigs were used. Biocox® was included in the piglet feed at a level of 60 ppm and the observation period lasted for 35 days. In the feed for growing pigs Biocox® was included at 60 ppm during the first 14 days and at 30 ppm th...

An experiment was carried out with a total of 2304 broilers over a period of 35 days in a 2 x 3 factorial design. The birds were randomly divided into 6 experimental groups housed in 48 floor pens (8 replicate pens/group), and were fed with whole wheat either in conventional amounts (10-21d, 15%; 22-35 d, 25%) or in high amounts (10-21d, 30%; 22-35d, 50%). Whole wheat was given as supplement to...

Batch culture fermentations were used to determine the effects of avoparcin, lasalocid, monensin, narasin, salinomycin, thiopeptin, tylosin, virginiamycin, monensin + tylosin combination, and two new ionophore compounds (RO22-6924/004 and RO21-6447/009) on lactic acid and volatile fatty acid (VFA) production. Ruminal fluid from cattle fed a high alfalfa hay diet was incubated with glucose for 1...

The use of iodobenzene diacetate and iodine under photolytic conditions provides and efficient method for the oxidative cyclization of spiroacetals bearing an hydroxyalkyl side chain to bis-spiroacetals. An overview is provided of the use of this reaction for the synthesis of several bis-spiroacetal containing natural products such as the polyether antibiotics salinomycin and CP44,161 and the s...