Pentavalent antimony complexes, such as sodium stibogluconate and sodium antimony gluconate (SAG), are still the first choice for chemotherapy against various forms of leishmaniasis, including visceral leishmaniasis, or kala-azar. Although the requirement of a somewhat functional immune system for the antileishmanial action of antimony was reported previously, the cellular and molecular mechani...

Neuroblasts of the statoacoustic ganglion (SAG) initially form in the floor of the otic vesicle during a relatively brief developmental window. They soon delaminate and undergo a protracted phase of proliferation and migration (transit-amplification). Neuroblasts eventually differentiate and extend processes bi-directionally to synapse with hair cells in the inner ear and various targets in the...

Unlike immortalized cell lines, normal human fibroblasts in culture undergo replicative senescence in which the number of population doublings is limited. While fibroblasts display a variety of changes as they senesce in vitro, little is known about how gene expression varies as a function of population doubling level. We have used differential hybridization screening to identify human genes th...

Light-emitting Diode (LED) lamps are more versatile and energy efficient compared with conventional light sources. This paper investigates two main problems related to power quality, namely, the harmonic generation from LED lamps and the effect of voltage sags on LED lamps. Laboratory tests on various LED lamps are conducted and the electrical characteristics of LED lamps are tapped under diffe...

Intrathymic expression of endogenous mouse mammary tumor virus (MMTV)-encoded superantigens (SAg) induces the clonal deletion of T cells bearing SAg-reactive T-cell receptor (TCR) Vbeta elements. However, the identity of the thymic antigen-presenting cells (APC) involved in the induction of SAg tolerance remains to be defined. We have analyzed the potential of dendritic cells (DC) to mediate th...

Ivan Sag died on September 10, 2013, after a long illness. He is survived by his wife, Stanford sociolinguistics professor Penny Eckert. In a career spanning four decades, he published over 100 articles and 10 books, centered on the theme of developing precise, implementable, testable, psychologically plausible, and scalable models of natural language, especially syntax and semantics. Sag earne...

Repair of severe skin tissue injury remains a great challenge and wound infection is still formidable problem. In this study, new macroporous antibacterial gelatin/alginate (SAG)-based hydrogels for repair were designed developed based on in-situ gas foaming method ion release strategy as result Mg-Cu particles degradation in the hydrogel matrix. The addition decreased storage modulus SAG, main...

Periodontitis is an inflammatory disease of the supporting tissues of the teeth. It is caused by an excessive immune response in which the complement system plays a key role. Both C-reactive protein (CRP) and salivary agglutinin (SAG) can activate the complement system, but it is unknown if CRP and SAG play a role in the etiology of periodontitis and in which areas of the oral cavity these prot...

BACKGROUND In modern radiotherapy, it is crucial to monitor the performance of all linac components including gantry, collimation system and electronic portal imaging device (EPID) during arc deliveries. In this study, a simple EPID-based measurement method has been introduced in conjunction with an algorithm to investigate the stability of these systems during arc treatments with the aim of en...

OBJECTIVE To evaluate the expressions of several apoptotic pathway proteins in relation to clinical parameters and survival in patients with cervical carcinoma. METHODS A total of 20 patients with clinically advanced staged carcinoma of cervix (International Federation of Gynecology and Obstetrics [FIGO] stage IIB-IVA) aged from 40 to 75 years were included in this study. The expression profi...