The substances responsible for saffron’s characteristic quality are crocins, picrocrocin, and safranal. The drying process is critical to the saffron quality as measured by levels of secondary metabolites, crocin (color and anti-tumor properties), picrocrocin (taste), and safranal (aroma). Four different dehydration methods were evaluated: Iranian traditional method (room temperature); dehy...

In this study, volatile and bioactive compositions of saffron samples collected from Khorasani region in Iran Razavi different locations Turkey containing Hatay (Kırıkhan, Iskenderun, Hassa Yayladağı counties), Karabük (Safranbolu county Yukarıbucak Ovacuma villages), Ankara (Ayaş, Nallıhan Polatlı Çukurova (Adana-Cukurova, Mersin-Tarsus Osmaniye-Kadirli counties) Antalya (Korkuteli county) wer...

Objective(s): Due to unsatisfactory response or intolerable side effects of current drugs, treatment of essential tremor remains inadequate. Thus, we aimed to investigate the protective and therapeutic effects of aqueous and ethanolic extracts of Crocus sativus (saffron), and its active consistent, safranal, on the harmaline-induced tremor in mice. Materials and Methods: To induce tremor, harma...

Background: Hexachlorobutadiene (HCBD) is a potent nephrotoxin in rodents, which can cause degeneration, necrosis and regeneration in renal tubular epithelial cells. It has been shown that safranal, the active ingredient of saffron, has a protective effect against ischemic injuries. The aim of this study was to examine the protective effect of safranal against HCBD-induced nephrotoxicity in rat...

Objective(s): Quinolinic acid (QA)-mediated excitotoxicity has been widely used as a model for studying neurodegenerative disorders. Recent studies suggested that saffron (Crocus sativus) or its active metabolite, i.e. safranal, exerts pharmacological actions on central nervous system including anxiolytic, anticonvulsant, and neuroprotective properties. The present study aimed to investigate th...

background & aim: saffron is one of the expensive spices known since antiquity for its color, flavor and medicinal properties. saffron is the dried stigma of crocus sativus plant. the three basic components of the stigma on which the qualitative characteristics of saffron depend are crocin (color), picrocrocin (taste), and safranal (aroma). the quality of saffron is a function of climatic c...

objectives: the aim of the present study was to investigate immunotoxic effect of safranal (saf), a main component of crocus sativus essential oil, using balb/c mice. materials and methods: saf was administered intraperitoneally at doses of 0.1, 0.5 and 1 ml/kg for 3 weeks. hystopathological examination of spleen and bone marrow, cellularity of spleen, delayed type of hypersensitivity (dth) res...

Cataract, which is the opacity inside clear ocular lens of eye, result in scattering visible light as it passes via and consequently deterioration optical image. The aim present study was to investigate whether safranal, an active constituent Crocus sativus L. stigmas, has a protective effect on cataract rat's pups. animals were randomly divided into five groups, each consisted 7 rat Group I se...

saffron or crocus sativus l. (c. sativus) has been widely used as a medicinal plant to promote human health, especially in asia. the main components of saffron are crocin, picrocrocin and safranal. the median lethal doses (ld50) of c. sativus are 200 mg/ml and 20.7 g/kg in vitro and in animal studies, respectively. saffron has been suggested to be effective in the treatment of a wide range of d...