We determined composition and relative roles of deubiquitylating proteins associated with the 26S proteasome in mammalian cells. Three deubiquitylating activities were associated with the 26S proteasome: two from constituent subunits, Rpn11/S13 and Uch37, and one from a reversibly associated protein, Usp14. RNA interference (RNAi) of Rpn11/S13 inhibited cell growth, decreased cellular proteasom...

The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by replicating selected results from a substantial number of high-profile papers in the field of cancer biology published between 2010 and 2012. This Registered report describes the proposed replication plan of key experiments from 'Interactions between cancer stem cells an...

Incorrect crystal data was deposited with the CCDC along with the original article. This led to further errors in the ESI, specifically in Fig. S10 and Fig. S11 as well as Tables S4, S7 and S13. Correct crystal data has been deposited with the CCDC to replace the original data and both the ESI and the crystal data for this article available online have since been replaced with corrected version...

A graph is called integral if all its eigenvalues (of the adjacency matrix) are integers. In this paper, the graphs S1(t) = K1,t, S2(n, t), S3(m,n, t), S4(m,n, p, q), S5(m,n), S6(m,n, t), S8(m,n), S9(m,n, p, q), S10(n), S13(m,n), S17(m,n, p, q), S18(n, p, q, t), S19(m,n, p, t), S20(n, p, q) and S21(m, t) are defined. We construct the fifteen classes of larger graphs from the known 15 smaller in...

The UV-induced mutagenesis of phage S13 that accompanies Weigle repair is known to require the products of the recA and umuDC genes, as does the UV-induced mutagenesis of the Escherichia coli chromosome. I found that UV-induced mutagenesis of phage S13 occurred in the absence of both the RecA and UmuC functions when the irradiated phage was photoreactivated. Furthermore, UV-induced phage mutati...