Automated adaptations of dithionite and urea-dithionite tube tests are accurate, reliable, inexpensive methods for detecting hemoglobin S. More than 3,000 individuals have been screened (120 determinations per hour; reagent cost, 2 to 4 cents per test). The dithionite reagent consists of potassium phosphate, sodium dithionite, and saponin. When S hemoglobin contacts this reagent, the red cells ...

If it is true that good problems produce good science, then it will be worthwhile to identify good problems, and even more worthwhile to discover the attributes that make them good problems. This discovery process is necessarily empirical, so we examine several challenge problems, beginning with Turing’s famous test, and more than a dozen attributes that challenge problems might have. We are le...

Several screening methods for detecting sickling hemoglobins are presently used in the clinical laboratory (1-6). The present procedure depends on the insolubility of reduced hemoglobin S in a 2.24 mol/liter phosphate buffer. The commercially available “Sickledex” (Ortho Diagnostics, Raritan, N.J. 08869) is also thought to be based on this principle (6). Our method was compared with the standar...

Our purpose was to demonstrate that 30-s tethered swimming test can be a useful tool to estimate swimming performance in short distance freestyle events. Thirteen high level adolescent swimmers (7 male and 6 female of 16.6 ± 1.0 and 15.8 ± 0.8 years old) performed a 30-s maximum effort in front crawl tethered swimming. Afterward, subjects completed 50-m and 100-m freestyle events at the Nationa...

In the U.S., there is no recent database of district-level test scores that is comparable across states. We construct and evaluate such a database for years 2009-2013 to support large-scale educational research. First, we derive transformations that link each state test score scale to the scale of the National Assessment of Educational Progress (NAEP). Next, we apply these transformations to a ...

The increased usage of embedded pre-designed reusable cores necessitates a core-based test strategy, in which cores are tested as separate entities. IEEE P1500 Standard for Embedded Core Test (SECT) is a standard-underdevelopment that aims at improving ease of reuse and facilitating interoperability with respect to the test of core-based system chips, especially if they contain cores from diffe...