Previous studies indicate that replicative lifespan in daughter cells of Sacchraromyces cerevisiae depends on the preferential inheritance of young, high-functioning mitochondria. We report here that mitochondria are functionally segregated even within single mother cells in S. cerevisiae. A high-functioning population of mitochondria accumulates at the tip of the mother cell distal to the bud....

A general view is that Schizosaccharomyces pombe undergoes symmetric cell division with two daughter cells inheriting equal shares of the content from the mother cell. Here we show that CTP synthase, a metabolic enzyme responsible for the de novo synthesis of the nucleotide CTP, can form filamentous cytoophidia in the cytoplasm and nucleus of S. pombe cells. Surprisingly, we observe that both c...

Na(+) and K(+) channel-blocking drugs have anti- and proarrhythmic effects. Their effects during fibrillation, however, remain poorly understood. We used computer simulation of a two-dimensional (2-D) structurally normal tissue model with phase I of the Luo-Rudy action potential model to study the effects of Na(+) and K(+) channel blockade on vulnerability to and termination of reentry in simul...

On April 2, 2012 the Eindhoven University of Technology published the first adaptive PhD thesis [4] describing the research on the adaptation language and engine GALE, and served (adaptively) by the GALE engine. The aim of the this research was twofold: to make the authoring of adaptive documents feasible without much technical knowledge, and to create an adaptation and user modeling service th...

AIM To describe the development and testing of a monitoring model with quantitative indicators or progress markers that could measure the progress of individual hospitals in the implementation of kangaroo mother care (KMC). METHODS Three qualitative data sets in the larger research programme on the implementation of KMC of the MRC Research Unit for Maternal and Infant Health Care Strategies i...

The aim of the demo is threefold. First, it introduces the current version of the annotation tool for discourse relations in the Prague Dependency Treebank 3.0. Second, it presents the discourse relations in the treebank themselves, including new additions in comparison with the previous release. And third, it shows how to search in the treebank, with focus on the discourse relations.

Abstract In her essay ‘The Ga(s)p’, M. NourbeSe Philip sketches a respirational poetics that embeds the precarity of African American breath in natal scene conspiration. gesture ‘radical hospitality’, every mother breathes for unborn baby. Her book Zong! , consisting words torn from legal document about massacre on slave ship, is described as ‘series ga(s)ps air with syllabic sounds attached or...

A study was made of the structure of the centrosome in the cell cycle in a nonsynchronous culture of pig kidney embryo (PE) cells. In the spindle pole of the metaphase cell there are two mutually perpendicular centrioles (mother and daughter) which differ in their ultrastructure. An electron-dense halo, which surrounds only the mother centriole and is the site where spindle microtubules converg...