نتایج جستجو برای: s disease pd
تعداد نتایج: 2167246 فیلتر نتایج به سال:
SUMMARY Hodgkin's disease has been known to medical practitioners for more than three centuries. The clinical and pathologic description of the disease published by Thomas. Hodgkin first in 183 2 when reported seven cases th-at he considered a new clinical entity. The incident, clinical feature, histologic, procedure of evaluation and staging of Hodgkin's disease are presented briefly. Part...
OBJECTIVE To investigate the accuracy of composite scores in classifying RA patients who are in remission using the absence of inflammatory activity detected by ultrasound (US) as a gold standard. METHODS Ninety-seven RA patients who were classified by their rheumatologists as being in remission were studied. Disease activity was assessed by the DAS-28 and simplified disease activity index (S...
PURPOSE The nonmotor symptoms (NMS) of Parkinson's disease (PD) are important factors for quality of life (QoL). Few studies on NMS have been conducted in Asian PD patients. Additionally, effects of anti-PD drugs on risk of NMS are still controversial. We therefore conducted this hospital-based cross-sectional study to examine the clinical factors, including concomitant anti-PD medication use, ...
Mutations in the LRRK2 (leucine-rich repeat kinase 2) gene are the most frequent genetic cause of PD (Parkinson's disease), and these mutations play important roles in sporadic PD. The LRRK2 protein contains GTPase and kinase domains and several protein-protein interaction domains. The kinase and GTPase activity of LRRK2 seem to be important in regulating LRRK2-dependent cellular signalling pat...
Swallowing difficulties and constipation were included in the first description of Parkinsons ́s syndrome from 1817 (Parkinson 1817). Since then, numerous studies have confirmed the magnitude of symptoms and addressed their pathophysiology. In spite of this, much remains to be determined and treatment of gastrointestinal dysfunction in Parkinson ́s disease (PD) is often unsatisfactory. Parkinson ́...
Background & Aims: There is no agreement on the protective effect of exercise on neurodegeneration processes, and the mechanisms responsible for exercise benefits in Parkinson disease (PD) yet. In this study we investigated the protective effect of 4 weeks of treadmill running with low intensity on the IGF-1, dopamine and tyrosine hydroxylase levels in the striatum of parkinsonian rats ind...
The effect of concurrent music on gait was investigated amongst Parkinson " s disease (PD) patients and age-matched control subjects. Ten people (mean age 66.6 ± 6.5 years) with idiopathic Parkinson " s disease and ten healthy age-matched (mean age 65.4 ± 6.3 years) control subjects completed steady state gait, dual task and obstacle negotiation trials in two differing test conditions; no music...
BACKGROUND Nonmotor symptoms (NMS) have a great impact on patients with Parkinson disease (PD). The Non-Motor Symptoms Scale (NMSS) is an instrument specifically designed for the comprehensive assessment of NMS in patients with PD. NMSS psychometric properties have been tested in this study. METHODS Data were collected in 12 centers across 10 countries in America, Asia, and Europe. In additio...
Parkinson’s disease (PD) is a neurodegenerative disorder that does not develop spontaneously in some animal species. PD can be induced experimentally in some laboratory animals including mouse, rat and horse. Globus pallidus (GP) and substantia nigra pars compacta (SNc) are damaged in patients with PD. The hallmark of PD is a progressive impaired control of movement, an alteration of autonomic ...
The field of molecular genetics has recently provided important clues to further understanding of the etiopathogenesis of idiopathic Parkins o n ’s disease (PD). Different mendelian forms of PD have been identified, establishing the concept of etiological heterogeneity in degenerative parkinsonisms (Table I, see over) (1-3). The genes and loci so far identified are responsible for only a very s...
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