BACKGROUND About 90% of patients with atopic dermatitis (AD) are colonized with Staphylococcus aureus. S. aureus worsens AD by secreting superantigens and structural molecules within the cell wall that induce skin inflammation. Therefore, S. aureus in the home may contribute to persistent skin inflammation and disease severity. OBJECTIVE To quantify S. aureus burden in homes of participants w...

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by neurofibrillary tangles, senile plaques, and loss of synapses. Many studies support the notion that oxidative stress plays an important role in AD pathogenesis. Previous studies from our laboratory employed redox proteomics to identify oxidatively modified proteins in the AD inferior parietal lobule (IPL) and hippocampus....

Atopic dermatitis (AD) is a chronic inflammatory skin disease with increasing prevalence over the last few decades. Various factors are known to aggravate the disease. In particular, wool and synthetic fabrics with harsh textile fibres, aggressive detergents and climatic factors may exacerbate AD. Cutaneous superinfection, particularly with Staphylococcus aureus, is also recognized as an import...

1 Eskildsen, S. F., Coupe, P., Fonov, V. S., Pruessner, J. C., & Collins, D. L. (2014). Structural imaging biomarkers of Alzheimer's disease: predicting disease progression. Neurobiology of Aging. Notes: Optimized magnetic resonance imaging (MRI)-based biomarkers of Alzheimer's disease (AD) may allow earlier detection and refined prediction of the disease. In addition, they could serve as valua...

This paper explores how the concept of Alzheimer’s disease (AD) is constructed through Spanish media and documentary films and how it is represented. The article analyses three documentary films and the cultural and social contexts in and from which they emerged: Solé ́s Bucarest: la memòria perduda [Bucharest: Memory Lost] (2007), Bosch ́s Bicicleta, cullera, poma [Bicycle, Spoon, Apple] (2010) ...

Mitochondrial dysfunction and synaptic loss are among the earliest events linked to Alzheimer's disease (AD) and might play a causative role in disease onset and progression. The underlying mechanisms of mitochondrial and synaptic dysfunction in AD remain unclear. We previously reported that nitric oxide (NO) triggers persistent mitochondrial fission and causes neuronal cell death. A recent art...

Alzheimer Disease (AD) is a neurodegenerative disorder and the most common form of dementia. Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. In vitro and animal studies have linked neuroinflammation to Alzheimer's disease (AD) pathology. Studies on marke...

The gene encoding NOS-I (NOS1) displays a complex transcriptional regulation, with nine alternative first exons. Exon 1c and 1f are the most abundant forms in the brain. A functional single nucleotide polymorphism (SNP) in exon 1c and a polymorphism in exon 1f, consisting of a variable number of tandem repeats (VNTR) originating short (S) and long (L) alleles, were studied in 184 patients with ...

a b s t r a c t   alzheimer's disease (ad) is a neurodegenerative disorder in geriatric people that characterized by reduction in memory and learning ability. attenuation of cholinergic system is the most likely hypothesis. therefore, potentiation of the cholinergic system via inhibition of acetylcholinesterase enzyme could improve and alleviate the symptoms of ad. a new series of isatin-based ...

There are many reasons for decrease of the functional activity of the brain like aging of the neurons, bacterial diseases and neuro inflammations. Nowadays, the effects of exercise on physical and mental health have been proven but its effects on motor functions as well as neuro inflammation is an issue that has recently been studding. Neuro inflammation is a mechanism that can be caused by B...