نتایج جستجو برای: rvr

تعداد نتایج: 402  

Journal: :ACS omega 2023

Hepatitis C virus (HCV) is one of the most prevalent pathogens which causes significant morbidity and mortality in 2% world’s population. Several interferon-stimulated genes (ISGs) are involved HCV clearance by interacting with viral proteins. Among these ISGs, tripartite motif (TRIM) family elevated during infection. This study aims to evaluate expression three TRIM chronic hepatitis patients,...

Journal: :Virus research 2010
Kay S Faaberg Marcus E Kehrli Kelly M Lager Baoqing Guo Jun Han

Prior studies on PRRSV strain VR-2332 non-structural protein 2 (nsp2) had shown that as much as 403 amino acids could be removed from the hypervariable region without losing virus viability in vitro. We utilized selected nsp2 deletion mutants to examine in vivo growth. Young swine (4 pigs/group; 5 control swine) were inoculated intramuscularly with one of 4 nsp2 deletion mutants (rΔ727-813, rΔ5...

Journal: :American journal of physiology. Renal physiology 1999
Severina M Jacinto John J Mullins Kenneth D Mitchell

The present study was performed to evaluate renal vascular responsiveness (RVR) to ANG II in hypertensive transgenic rats [TGR; strain TGR(mRen2)27] harboring the mouse ren-2 renin gene. Renal blood flow (RBF) responses to either intravenous or intrarenal arterial administration of ANG II were assessed in pentobarbital sodium-anesthetized female heterozygous TGR (9-12 wk old) and age-matched tr...

Journal: :Gastroenterology 2010
Alexander J Thompson Andrew J Muir Mark S Sulkowski Dongliang Ge Jacques Fellay Kevin V Shianna Thomas Urban Nezam H Afdhal Ira M Jacobson Rafael Esteban Fred Poordad Eric J Lawitz Jonathan McCone Mitchell L Shiffman Greg W Galler William M Lee Robert Reindollar John W King Paul Y Kwo Reem H Ghalib Bradley Freilich Lisa M Nyberg Stefan Zeuzem Thierry Poynard David M Vock Karen S Pieper Keyur Patel Hans L Tillmann Stephanie Noviello Kenneth Koury Lisa D Pedicone Clifford A Brass Janice K Albrecht David B Goldstein John G McHutchison

BACKGROUND & AIMS We recently identified a polymorphism upstream of interleukin (IL)-28B to be associated with a 2-fold difference in sustained virologic response (SVR) rates to pegylated interferon-alfa and ribavirin therapy in a large cohort of treatment-naive, adherent patients with chronic hepatitis C virus genotype 1 (HCV-1) infection. We sought to confirm the polymorphism's clinical relev...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1997
S G Ramella-Virieux J P Steghens A Barbieux P Zech N Pozet A Hadj-Aïssa

BACKGROUND Extracellular types (high-Na) of cold-storage solution (CSS) have been shown to be more effective in preserving kidneys than intracellular CSS (high-K). On the other hand, calcium entry blockers (CEB) have been demonstrated to improve graft function when administered after and/or prior to transplantation. The ischaemia reperfusion syndrome involves, in part, an alteration in intracel...

2012
N Reau F M Hamzeh E Lentz X Zhou D Jensen

Approximately 50% of patients with hepatitis C virus (HCV) genotype 1 treated with peginterferon alfa-2a/ribavirin discontinue treatment early or experience a suboptimal response despite 48 weeks of therapy. The objective of this analysis was to develop a model to identify nonrapid virologic response (non-RVR) patients who may be candidates for intensified therapy that would increase treatment ...

Journal: :Journal of applied physiology 1999
T D Yanowitz A C Yao K D Pettigrew J C Werner W Oh B S Stonestreet

The purpose of this study was to characterize postnatal changes in regional Doppler blood flow velocity (BFV) and cardiac function of very-low-birthweight infants and to examine factors that might influence these hemodynamic changes. Mean and end-diastolic BFV of the middle cerebral and superior mesenteric arteries, cardiac output, stroke volume, and fractional shortening were measured in 20 in...

Journal: :Shock 2017
Ari Moskowitz Kenneth P Chen Avraham Z Cooper Abdullah Chahin Mohammad M Ghassemi Leo Anthony Celi

PURPOSE Atrial fibrillation with rapid ventricular response (RVR) is common during critical illness. In this study, we explore the comparative effectiveness of three commonly used drugs (metoprolol, diltiazem, and amiodarone) in the management of atrial fibrillation with RVR in the intensive care unit (ICU). METHODS Data pertaining to the first ICU admission were extracted from the Medical In...

Journal: :Journal of the American Society of Nephrology : JASN 2000
E Turkstra B Braam H A Koomans

Increases in renal perfusion pressure will induce shear stress-mediated nitric oxide (NO) release, which could oppose autoregulation of renal blood flow (RBF). Although cardiac, cerebral, and mesenteric autoregulation is enhanced during nitric oxide (NO) synthesis inhibition, this has not been reported for renal autoregulation of blood flow. In the present study, the lower limit and efficiency ...

Journal: :IEEE Transactions on Industrial Electronics 2022

Relevance vector regression (RVR) is a useful tool for degradation modeling and remaining life (RUL) prediction. However, most RVR models are 1-D processes can only handle univariate observations. This article proposes path-based RUL prediction framework using dynamic multivariate relevance model. Specifically, multistep model established describing the dynamics extending classical into one wit...

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