A photoactivated ruthenium(II) arene complex has been conjugated to two receptor-binding peptides, a dicarba analogue of octreotide and the Arg-Gly-Asp (RGD) tripeptide. These peptides can act as "tumor-targeting devices" since their receptors are overexpressed on the membranes of tumor cells. Both ruthenium-peptide conjugates are stable in aqueous solution in the dark, but upon irradiation wit...

A variety of 3-substituted benzisoxazoles were reduced with hydrogen using the chiral ruthenium catalyst, {RuCl(p-cymene)[(R,R)-(S,S)-PhTRAP]}Cl. The ruthenium-catalyzed hydrogenation proceeded in high yield in the presence of an acylating agent, affording α-substituted o-hydroxybenzylamines with up to 57% ee. In the catalytic transformation, the N-O bond of the benzisoxazole substrate is reduc...

A novel zerovalent ruthenium complex with a π-acidic ligand, Ru(η (6)-cyclooctatriene)(η (2)-dimethyl fumarate)2 (1), was prepared from Ru(η (4)-cyclooctadiene)(η (6)-cyclooctatriene) [Ru(cod)(cot)]. Complex 1 or Ru(cod)(cot) catalyzes various new carbon-carbon bond-forming reactions that include the [2 + 2] cycloaddition of alkenes and alkynes via ruthenacycles, the creation of a new hydrocarb...

Ruthenium red was found to inhibit actin-activated myosin Mg(2+)-ATPase in smooth muscle and to bind to myosin heavy chain, but not to F-actin. The inhibition by Ruthenium red of actin-activated Mg(2+)-ATPase was of the competitive type with respect to actin (Ki 4.4 microM) and of the non-competitive type with respect to ATP (Ki 6.6 microM). However, Ruthenium red scarcely dissociated the acto-...

The successful synthesis of high-entropy alloy (HEA) nanoparticles, a long-sought goal in materials science, opens new frontier science with applications across catalysis, structural alloys, and energetic materials. Recently, Co25Mo45Fe10Ni10Cu10 HEA made earth-abundant elements was shown to have high catalytic activity for ammonia decomposition, which rivals that state-of-the-art, but prohibit...

A ruthenium benzylidene complex with a neutral bidentate N-heterocyclic carbene was prepared and evaluated in ring-closing metathesis of diallyl substrates. Reaction with AgPF6 to generate a four-coordinate complex produced an unexpected dicationic ruthenium benzyl degradation product through nucleophilic attack of the NHC ligand on the benzylidene carbon.

Over the past few years, the organometalled compounds, including ruthenium, gained a lot of attention as anticancer agents. We report on the clioquinol-ruthenium complex [Ru(η6-p-cymene)(Cq)Cl] as a potent inhibitor of cathepsin B, a lysosomal cysteine peptidase, involved in tumour cell invasion and metastasis. In the low micromolar concentration range, the clioquinol-ruthenium complex did not ...

The key factor to improve the electrochemical performance of Li-O₂ batteries is to find effective cathode catalysts to promote the oxygen reduction and oxygen evolution reactions. Herein, we report the synthesis of an effective cathode catalyst of ruthenium nanocrystals supported on carbon black substrate by a surfactant assisting method. The as-prepared ruthenium nanocrystals exhibited an exce...

The effects of the condensation product of N-methyl-p-methoxyphenethylamine with formaldehyde (compound 48/80) and ruthenium red on the partial reactions of the catalytic cycle of the sarcoplasmic reticulum Ca2+-ATPase of skeletal muscle were studied. The ATPase activity and both Ca2+ and Sr2+ uptake were inhibited by compound 48/80 when oxalate was used as a precipitating agent. The degree of ...