The outcome of in vitro fertilization (IVF) depends substantially on the effectiveness of controlled ovarian hyperstimulation (COH) induced by administration of follicle-stimulating hormone (FSH). In COH, endogenously produced estrogens extend the action of FSH in stimulating folliculogenesis. We determined the associations between genetic variations in estrogen receptor ESR1 and ESR2 genes and...

PIT1 was chosen as a candidate gene to investigate its associations with growth, meat quality and carcass composition traits in the pig. PIT1 is known as the pituitary-specific activator of the growth hormone in several mammals. Furthermore, PIT1 is a positive regulatory factor of prolactin and thyroid-stimulating hormone beta. PIT1 is a member of the POU-domain family of genes and is located o...

b-lactoglobulin (coded by the b-lg gene) is the major milk whey protein in ruminants. studies have shown that this protein is polymorphic in many breeds of sheep as a result of a single base pair substitution in the b-lg gene that also gives rise to rsai restriction fragment length polymorphism (rflp). blood samples were collected from 391 animals belonging to 5 iranian and 6 russian sheep bree...

Human cancer risk assessment using molecular genetic techniques is a rapidly emerging field. Many studies suggest that both inherited and acquired genetic predispositions play an important role in carcinogenesis. Cytochrome P450 (CYP) 2E1 is involved in the metabolic activation of N-nitrosamines and other low molecular weight compounds. A recently described genetic polymorphism of CYP2E1 [DraI ...

BACKGROUND Due to the differences in the oncogenic activity of human papillomaviruses (HPV), it is clinically important to accurately identify HPV types in a simple and time effective manner. OBJECTIVES We aimed at developing a straightforward and cost-effective assay to individually identify all mucosal HPVs, based on the amplification of L1 gene using MY09/11 primers, and subsequent restric...

objective(s): iran is considered as one of the high-prevalence areas for β-thalassemia with a rate of about 10% carrier frequency. molecular diagnosis of the disease is performed both by direct sequencing and indirectly by the use of polymorphic markers present in the beta globin gene cluster. however, to date there is no reliable information on the application of the markers in the iranian pop...

Cytochrome 2E1, has been reported to participate in the pathogenic process of gastrointestinal (GI) cancers. Previous studies showed that the results are conflicting. To clarify the association between cytochrome CYP2E1 RsaI polymorphism and risk of gastrointestinal cancers, we conducted this meta-analysis of 35 studies with 8267 cases and 11001 controls. Odds ratios (ORs) with 95% confidence i...

There is a possible association between acute leukemia (AL) and polymorphisms in genes coding for cytochrome P4502E1 (CYP2E1) and myeloperoxidase (MPO), the enzymes both involved in the metabolism and bioactivation of xenobiotic compounds, including benzene especially. Previous studies reported conflicting results. Therefore, a meta-analysis of available molecular epidemiologic studies was perf...