نتایج جستجو برای: rora
تعداد نتایج: 204 فیلتر نتایج به سال:
Both genetic and environmental factors are important for the development of allergic diseases. However, a detailed understanding of how such factors act together is lacking. To elucidate the interplay between genetic and environmental factors in allergic diseases, we used a novel bioinformatics approach that combines feature selection and machine learning. In two materials, PARSIFAL (a European...
Upon activation, naive CD4(+) T cells differentiate into different lineages of effector T(h) subsets. Each subset is characterized by its unique cytokine profile and biological functions. T(h)17, a newly described T(h) subset that produces IL-17, IL-17F and IL-22 in preference to other cytokines, has been shown to play an important role in clearing specific pathogens and in inducing autoimmune ...
RORA (RAR-Related Orphan Receptor Alpha) regulates estrogen synthesis by transcribing steroid related genes. Litter size is an important reproductive trait associated with synthesis. Therefore, it critical to investigate the relationship between gene and sheep litter size. In this study, a 23 base pair nucleotide sequence mutation in called effect of on productivity offspring were investigated....
OBJECTIVE Atherosclerosis is a chronic inflammatory condition and is one of the main causes of death worldwide. Macrophages play important roles in the formation of atherosclerotic plaques. Apoptosis is progressively observed while plaques develop, although the precise mechanisms and outcomes of apoptosis in atherosclerosis development and progression are still contradictory. This study was con...
Abstract Memory B cells (MBCs) are long-lived and produce high-affinity, generally, class-switched antibodies. Here we use a multiparameter approach involving CD27 to segregate naïve (NBCs), IgD+ unswitched (unsw) MBCs IgG+ or IgA+ (sw) from humans of different age, sex race. Conserved antibody variable gene expression indicates that emerge through unbiased selection NBCs. Integrative analyses ...
Abstract Background Cell pyroptosis has a strong proinflammatory effect, but it is unclear whether of liver macrophages exacerbates tissue damage during ischemia‒reperfusion (I/R) injury. Maresin1 (MaR1) anti-inflammatory and can suppress macrophage needs further study. Methods This study aimed to investigate MaR1 alleviate I/R injury by inhibiting pyroptosis. The effects on cell mitochondrial ...
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