نتایج جستجو برای: rorγt
تعداد نتایج: 603 فیلتر نتایج به سال:
Immune dysregulation drives the pathogenesis of chronic inflammatory, autoimmune, and dysplastic disorders. While often intended to address localized pathology, most immune modulatory therapies are administered systemically and carry inherent risk of multiorgan toxicities. Here, we demonstrate, in a murine model of spontaneous gastrointestinal polyposis, that site-specific uptake of orally admi...
BackgroundSepsis is a common complication of many diseases and associated with high morbidity mortality rates. Astragalus can improve humoral innate immunity, inhibit inflammatory responses, protect immune cells organs from damage. However, to the best our knowledge there are no reports on whether astragalus regulate intestinal function during sepsis.MethodsIn this study, rat cecal ligation pun...
Relationship between Th17-mediated immunity and airway inflammation in childhood neutrophilic asthma
Abstract Background The pathogenetic mechanisms of neutrophilic asthma are not well understood now. Whether T helper (Th)17-mediated immunity contributes to the pathogenesis in human is still under investigation. aim this study was explore relationship between Th17-mediated and airway inflammation childhood asthma. Methods Twenty-eight children with exacerbated without using any glucocorticoids...
Abstract Microbial colonization of the mammalian intestine elicits inflammatory or tolerogenic T cell responses, but mechanisms controlling these distinct outcomes remain poorly understood, and accumulating evidence indicates that aberrant immunity to intestinal microbiota is causally associated with infectious, malignant diseases. Here we define a critical pathway fate versus cells respond exp...
Introduction The three groups of helper innate lymphoid cells (ILCs), namely ILC1, ILC2 and ILC3, have been identified by flow cytometry combinations cell surface markers. Here, we review various ways ILCs are currently identified, focusing on potential problems their solutions. first step to identify all is exclude other lymphocytes myeloid lineage-specific markers (Lin). However, the Lin cock...
Regulatory T (Treg) cells can express the transcription factors T-bet and GATA3 but the function of this expression and whether such cells represent stable subsets is still unknown. By using multiple reporter tools, we show that the expression of T-bet and GATA3 in Treg cells is dynamically influenced by the cytokine environment. Treg cell-specific deletion of either Tbx21 or Gata3 genes singly...
BACKGROUND Pingchuan Formula (PCF) is a traditional Chinese recipe. PCF improves chronic airway inflammation by correcting the imbalance of T-helper cell ratio. The purpose of this study was to investigate the effect of PCF on pathological changes in the lungs of asthmatic mice in terms of Treg/Th17 balance. METHODS A bronchial asthma BALB/c mouse model was established using the ovalbumin exc...
INTRODUCTION Our objective in the present study was to determine the signaling pathway of interleukin 10 (IL-10) for modulating IL-17 expression in macrophages and the importance of this mediation in collagen-induced arthritis (CIA). METHODS IL-10-knockout (IL-10⁻/⁻) mice and wild-type (WT) mice were immunized with chicken type II collagen (CII) to induce arthritis. The expression levels of I...
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