Evidence is emerging that the closely related ROCK1 and ROCK2 serine/threonine kinases support the invasive and metastatic growth of a spectrum of human cancer types. Therefore, inhibitors of ROCK are under preclinical development. However, a key step in their development involves the identification of genetic biomarkers that will predict ROCK inhibitor antitumor activity. One identified mechan...

Abstract Murujuga in Western Australia has the largest concentration of ancient rock engravings (petroglyphs) world. However, art is potentially threatened by local industrial air pollution, particular acid rain, but unambiguous scientific evidence still missing. Here, we report on results an accelerated weathering experiment, simulating weather and climate conditions that was designed performe...

This work aims at figuring out the spatial relationships between the geophysical and geological models in a case study pertaining to copper-sulfide mineralization through an integrated 3D analysis of favorable target. The Ghalandar Skarn-Porphyry Cu Deposit, which is located in NW Iran, is selected for this research work. Three geophysical surveys of direct current electrical resistivity and in...

Most species of Ischnochiton are habitat specialists and are almost always found underneath unstable marine hard-substrata such as boulders. The difficulty of experimenting on these chitons without causing disturbance means little is known about their ecology despite their importance as a group that often contributes greatly to coastal species diversity. In the present study we measured among-b...

The classification of natural images is an essential task in computer vision and pattern recognition applications. Rock images are the typical example of natural images, and their analysis is of major importance in rock industries and bedrock investigations. Rocks are mainly classified into three types. They are Igneous, Metamorphic and Sedimentary. They are further classified into Andesite, Ba...

Rho, a member of the Rho small G protein family, regulates the formation of stress fibers and focal adhesions in various types of cultured cells. We investigated here the actions of ROCK and mDia, both of which have been identified to be putative downstream target molecules of Rho, in Madin-Darby canine kidney cells. The dominant active mutant of RhoA induced the formation of parallel stress fi...

Fracture mechanics is a vital component involved in studying the exact behavior of rock materials. Detection and assessment of the behavior of rock joints injected by grout plays an important role in numerical modelling in rock mechanic projects. The importance of mechanisms associated with initiation and propagation of cracks due to hydraulic fracturing has led to a considerable interest in in...

Finch trichomonosis, caused by Trichomonas gallinae, emerged in the Canadian Maritime provinces in 2007 and has since caused ongoing mortality in regional purple finch (Carpodacus purpureus) and American goldfinch (Carduelis tristis) populations. Trichomonas gallinae was isolated from (1) finches and rock pigeons (Columbia livia) submitted for post-mortem or live-captured at bird feeding sites ...

THE SMALL GTPase Rho has three isoforms, RhoA, RhoB, and RhoC, of which RhoA has been widely studied. When the Rho gene was first cloned in 1980s, the physiological function of Rho was thought to be similar to its relatives, the Ras proteins. Unexpectedly, Rho was soon found to be crucial in the regulation of the actin cytoskeleton (10, 11). In the following years, many Rho downstream targets w...