Axonal injury due to prostatectomy leads to Wallerian degeneration of the cavernous nerve (CN) and erectile dysfunction (ED). Return of potency is dependent on axonal regeneration and reinnervation of the penis. Following CN injury (CNI), RhoA and Rho-associated protein kinase (ROCK) increase in penile endothelial and smooth muscle cells. Previous studies indicate that nerve regeneration is ham...

Field and laboratory studies have indicated that rock fragments in the topsoil may have a large impact on soil properties, soil quality, hydraulic, hydrological and erosion processes. In most studies, the investigated rock fragments still remain visible at the soil surface and only properties of these visible rock fragments are used for predicting runoff and soil loss. However, there are indica...

Analysis of advanced displacement in construction progress of tunnel excavation with weak surrounding rock is carried out by numerical method and comparison of model test result. In allusion to the problems of regional landslides and extruded large-deformation seriously impacting the stability of rock mass in construction process of large-section tunnel with weak surrounding rock, the elastic-p...

* Corresponding author – [email protected] Tel: 414-229-4126 Fax:414-229-6958 ABSTRACT Understanding the fundamental tribology associated with the cutting of rock under extremely high pressure and high temperature (HPHT) conditions are extremely important in mining and drilling operations. In this paper, a rock fragmentation process is simulated during mechanical cutting of rock using an explicit...

The rocks are formed through very complex processes and the complex behaviour of rock masses is dominated by the planes of weaknesses . Rock mass consists of intact rock and discontinuities. Many rocks show strain softening behaviour under loads. In this paper, the constitutive models for intact rocks and rock joints are presented. These form the basis for the development of constitutive models...

Rho-Rho kinase (Rho-ROCK) triggers an intracellular signalling cascade that regulates cell survival, death, adhesion, migration, neurite outgrowth and retraction and influences the generation and development of several neurological disorders. Although Fasudil, a ROCK inhibitor, effectively suppressed encephalomyelitis (EAE), certain side effects may limit its clinical use. A novel and efficient...

Rho-associated kinase (ROCK) signaling plays a fundamental role in regulating cell morphology, adhesion, and motility. Aberrant expression of ROCK is related to tumor metastases and poor clinical outcome. Here, we show that ROCK expression is increased in metastatic human mammary tumors and breast cancer cell lines compared with nonmetastatic tumors and cell lines. Overexpression of ROCK confer...

In order to compare and analyze the seismic response characteristics of a safety-related nuclear structure on non-rock site in condition raft pile group foundations under unidirectional multidirectional motion input, large-scale shaking table test soil-nuclear system was carried out this paper. test, soil uniform silted clay, shear wave velocity 213 m/s. Considering similarity superstructure na...

rock selection in modeling and simulation studies is usually based on two techniques; routinely defined rock types and those defined by special core analysis (scal). the challenge in utilizing these two techniques is that they are frequently assumed to be the same, but in practice, static rock-types (routinely defined) are not always representative of dynamic rock-types (scal defined) in the re...

In terms of target detection and classification, scattering from exposed rock on the seafloor, (i.e., individual rocks and rock outcrops) presents some of the most difficult challenges for modern MCM and ASW sonar systems in shallow water. Work on characterizing, modeling and simulating mean levels, and other statistical measures of acoustic scattering from rocks and rock outcrops is therefore ...