BACKGROUND AND PURPOSE A 6-base insertion (6bINS) polymorphism in intron 7 of the endoglin gene (ENG), which codes for a component of the transforming growth factor-beta receptor complex, was reported to be associated with intracranial aneurysm (IA) in a Japanese population. A recent report using a white population could not replicate the association. We tested for this association with high st...

Endoglin is a TGF-beta superfamily receptor critical for endothelial cell function. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia type I (HHT1), and clinical signs of disease are generally more evident later in life. We previously showed that systemic vessels of adult Eng heterozygous (Eng(+/-)) mice exhibit increased vasorelaxation due to uncoupling of endoth...

1Associate Member of ASCE, Ph.D., Assoc. Professor, Dept. of Civil and Env. Eng., Stanford Univ., and Director, Center for Integrated Facility Engineering (Terman Eng. Ctr., 380 Panama Mall, Stanford, CA 94305-4020, USA) E-mail:[email protected] 2Ph.D., Sr. Research Scientist, Dept. of Civil and Env. Eng., Stanford Univ. and Executive Director, Center for Integrated Facility Engineering (CIF...

Electrical Substrate Elimination in 135 Consecutive Patients With Brugada Syndrome Carlo Pappone, MD, PhD; Josep Brugada, MD, PhD; Gabriele Vicedomini, MD; Giuseppe Ciconte, MD; Francesco Manguso, MD, PhD; Massimo Saviano, MD; Raffaele Vitale, MD; Amarild Cuko, MD; Luigi Giannelli, MD; Zarko Calovic, MD; Manuel Conti, MD; Paolo Pozzi, Eng; Andrea Natalizia, PhD, Eng; Simonetta Crisà, Eng; Valer...

Dept. of Nuclear, Plasma, and Radiological Eng., University of Illinois at Urbana-Champaign, [email protected] Dept. of Nuclear, Plasma, and Radiological Eng., University of Illinois at Urbana-Champaign, [email protected] South Texas Project Nuclear Operating Company, [email protected] South Texas Project Nuclear Operating Company, [email protected] Computational Science and Engineerin...

Pete Seiler Mechanical Eng. Dept. U. of California-Berkeley Berkeley, CA 94720-1740, USA Phone: 1-510-642-6933 Fax: 1-510-642-6163 [email protected] Bong-Sob Song Mechanical Eng. Dept. U. of California-Berkeley Berkeley, CA 94720-1740, USA Phone: 1-510-642-6933 Fax: 1-510-642-6163 [email protected] J. Karl Hedrick Mechanical Eng. Dept. U. of California-Berkeley Berkeley,...

Two trials were conducted to determine the effect of energy source (ENG) and ruminally degradable protein (RDP) on lactating cow performance and intake and digestion in beef steers. In Trial 1, 78 cow-calf pairs were used in a 2 x 2 factorial design to determine the effect of ENG (corn or soyhulls; SH) and RDP (with our without sunflower meal) to a forage diet for lactating beef cows. The basal...

The functional mechanisms involved in angiogenesis and the potential role of endoglin (ENG), recently described as a new marker for this process, have not been explored in Myelodysplastic Syndromes (MDS). In order to gain insight in MDS angiogenesis a combined analysis in bone marrow (BM) of gene expression levels, angiogenesis-related soluble factors and functional angiogenesis-related studies...

BACKGROUND Hereditary hemorrhagic telangiectasia (HHT) is a vascular disorder characterized by epistaxis, arteriovenous malformations, and telangiectases. The majority of the patients have a mutation in the coding region of the activin A receptor type II-like 1 (ACVRL1) or Endoglin (ENG) gene. However, in approximately 15% of cases, sequencing analysis and deletion/duplication testing fail to i...

Transforming growth factor-β (TGF-β) plays a pivotal role in renal fibrosis. Endoglin, a 180 KDa membrane glycoprotein, is a TGF-β co-receptor overexpressed in several models of chronic kidney disease, but its function in renal fibrosis remains uncertain. Two membrane isoforms generated by alternative splicing have been described, L-Endoglin (long) and S-Endoglin (short) that differ from each o...