نتایج جستجو برای: rna activated protein kinase pkr

تعداد نتایج: 1597309  

Journal: :Diabetes 2021

MicroRNAs (miRNAs) are noncoding small RNAs that regulate various pathophysiological cellular processes. Here we reported expression of the miR-378 family was significantly induced by metabolic inflammatory inducers, a high-fructose diet, and cytokine TNF?. Hepatic miRNA profiling revealed miR-378a highly upregulated which, in turn, targeted 3'-UTR PPAR? mRNA, impaired mitochondrial fatty acid ...

2002
Jeffrey O. Langland Song Jin Bertram L. Jacobs

Plant virus or viroid infection stimulates the phosphorylation of a plant-encoded protein of M, 68,000 to 70,000 (now termed pPKR) that is associated with double-stranded RNA-stimulated protein kinase activity. Using various biochemical and immunological comparisons, we have demonstrated that this plant protein is an analog of the mammalian PKR enzymes. pPKR is both cytosolic and ribosome assoc...

Journal: :Journal of applied physiology 2011
G S Supinski L A Callahan

Diaphragm caspase-8 activation plays a key role in modulating sepsis-induced respiratory muscle dysfunction. It is also known that double-stranded RNA-dependent protein kinase (PKR) is a regulator of caspase-8 activation in neural tissue. We tested the hypothesis that the PKR pathway modulates sepsis-induced diaphragmatic caspase-8 activation. We first evaluated the time course of diaphragm PKR...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1995
R C Patel P Stanton N M McMillan B R Williams G C Sen

The interferon-inducible double-stranded (ds) RNA-activated protein kinase (PKR) exhibits antiviral, anticellular, and antitumor activities. The mechanisms of its enzymatic activation by autophosphorylation and of the observed transdominant inhibitory phenotype of enzymatically inactive mutants have invoked PKR dimerization. Here we present direct evidence in support of PKR-PKR interaction. We ...

مهاجری, نسرین, کاظمی, بهرام,

Normal 0 false false false EN-US X-NONE AR-SA /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal" mso-tstyle-rowband-size:0 mso-tstyle-colband-size:0 mso-style-noshow:yes mso-style-pri...

Journal: :Carcinogenesis 2007
Tatyana A Zykova Feng Zhu Yiguo Zhang Ann M Bode Zigang Dong

Double-stranded RNA-dependent protein kinase R (PKR) has been implicated in anti-viral (antitumor) and apoptotic responses. PKR is activated by extracellular stresses and phosphorylates the alpha subunit of protein synthesis initiation factor eIF2, thereby inhibiting protein synthesis and impeding virus multiplication. Phosphorylation of eIF2alpha in mammalian cells has been shown to be increas...

Journal: :Blood 2015
Xiaodong Cheng Michael Byrne Kevin D Brown Marina Y Konopleva Steven M Kornblau Richard L Bennett W Stratford May

Increased expression of the interferon-inducible double-stranded RNA-activated protein kinase (PKR) has been reported in acute leukemia and solid tumors, but the role of PKR has been unclear. Now, our results indicate that high PKR expression in CD34(+) cells of acute myeloid leukemia (AML) patients correlates with worse survival and shortened remission duration. Significantly, we find that PKR...

Journal: :The Journal of biological chemistry 2002
Chi-Wu Chen Yeou-Guang Tsay Hui-Lin Wu Chi-Hua Lee Ding-Shinn Chen Pei-Jer Chen

Hepatitis D virus (HDV) encodes two proteins, the 24-kDa small delta antigen (S-HDAg) and 27-kDa large delta antigen (L-HDAg) in its single open reading frame. Both of them had been identified as nuclear phosphoproteins. Moreover, the phosphorylated form of S-HDAg was shown to be important for HDV replication. However, the kinase responsible for S-HDAg phosphorylation remains unknown. Therefore...

2016
Amr A.A. Gamil Cheng Xu Stephen Mutoloki Øystein Evensen

The double-stranded RNA-activated protein kinase R (PKR) is a Type I interferon (IFN) stimulated gene that has important biological and immunological functions. In viral infections, in general, PKR inhibits or promotes viral replication, but PKR-IPNV interaction has not been previously studied. We investigated the involvement of PKR during infectious pancreatic necrosis virus (IPNV) infection u...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید