The study compares the efficacy of risperidone and haloperidol in patients of schizophrenia on various clinical and psychosocial parameters.In the present open, comparative study, in patients suffering from schizophrenia (DSM-IV), 50 patients each were randomly treated with risperidone and haloperidol over a period of 1 year. The clinical improvement was judged on PANSS (Positive and Negative S...

OBJECTIVE The authors examined the developmental impact and temporal characteristics of risperidone-associated weight change. METHOD Weight change was measured for 63 children and adolescents with autism treated with risperidone for 6 months. Change in serum leptin levels after 2 months was examined as a predictor of final weight gain in mixed regression models that controlled for site, gende...

OBJECTIVE This study aimed to compare the efficacy of long-acting risperidone and zuclopenthixol in subjects with schizophrenia and substance abuse. METHOD A total of 115 subjects with schizophrenia and substance use disorders were enrolled for an open, randomized, controlled, 6-month follow-up study. Fifty-seven subjects were selected for treatment with long-acting injectable risperidone, wh...

Antipsychotic medication is considered the cornerstone of the treatment in elderly patients with schizophrenia. Long acting risperidone injection was the first antipsychotic available for use in this group of patients. Current scientific literature revealed that long-acting risperidone is effective in treating the positive and negative symptoms of schizophrenia and some improvements in cognitio...

A simple, specific, accurate, and precise reverse phase liquid chromatographic method was developed and validated for the estimation of risperidone in tablet dosage forms. A Phenomenex Gemini C-18, 5 mum column having 250x4.6 mm i.d. in isocratic mode, with mobile phase containing methanol: acetonitrile: 50 mM potassium dihydrogen orthophosphate (80:10:10 v/v) was used. The flow rate was 1.3 ml...

BACKGROUND The treatment of schizophrenia with multiple antipsychotic drugs is common, but the benefits and risks are not known. METHODS In a randomized, double-blind study, we evaluated patients with schizophrenia and a poor response to treatment with clozapine. The patients continued to take clozapine and were randomly assigned to receive eight weeks of daily augmentation with 3 mg of rispe...

Hyperprolactinemia can be a complication of conventional neurolepics as well as risperidone. We report the third case of attenuation of risperidone-induced hyperprolactinemia by aripiprazole.

how to cite this article: fayyazi a, salari e, khajeh a, ghajarpour a. a comparison of risperidone and buspirone for treatment of behavior disorders in children with phenylketonuria. iran j child neurol. 2014 autumn; 8(4):33-38. abstract objective many patients with late-diagnosed phenylketonuria (pku) suffer from severe behavior problems. this study compares the effects of buspirone and risper...

BACKGROUND This study examined the efficacy and safety of N-acetylcysteine (NAC) augmentation for treating irritability in children and adolescents with autism spectrum disorders (ASD). METHOD Forty children and adolescents met diagnostic criteria for ASD according to DSM-IV. They were randomly allocated into one of the two groups of NAC (1200 mg/day)+risperidone or placebo+risperidone. NAC a...

OBJECTIVE To test the hypothesis that administration of risperidone to healthy subjects produces reductions in metabolism in the frontal cortex similar to those produced by administration of risperidone to patients experiencing a first episode of schizophrenia. METHODS Positron emission tomography was used to measure the changes in regional metabolism produced by a single 2-mg dose of risperi...