The I1 subtype of imidazoline receptors (I1R) is a plasma membrane protein that is involved in diverse physiological functions. Available radioligands used so far to characterize the I(1)R were able to bind with similar affinities to alpha2-adrenergic receptors (alpha2-ARs) and to I1R. This feature was a major drawback for an adequate characterization of this receptor subtype. New imidazoline a...

It is known that moxonidine acts as an agonist at presynaptic 2-adrenoceptors of the postganglionic sympathetic nerve terminals and leads to a reduction in noradrenaline release. In addition, it is conceivable that I1-binding sites located in other regions of the preand postganglionic sympathetic neurons are involved in this effect. Our aim was to investigate whether and to what extent activati...

Measurement of regional sympathetic activity in lean essential hypertension patients using electrophysiologic (sympathetic nerve recording) and neurochemical (measurement of norepinephrine spillover) techniques demonstrates activation of sympathetic outflow to the heart, kidneys, and skeletal muscle vasculature in younger (< 45 years) patients. The increase in sympathetic activity is a mechanis...

12. Rahman SN, Abraham WT, Van Putten VJ, Hasbargen JA, 20. Rump LC, Letalek T, Oberhauser V. Sympathetic neurotransmitters ATP, neuropeptide and noradrenaline induce Schrier RW. Increased norepinephrine secretion in patients with proliferation of human visceral glomerular epithelial cells. the nephrotic syndrome and normal glomerular filtration rates: Hypertension 1999; 34: 711 evidence for pr...

The I1 subtype of imidazoline receptors (I1R) is a plasma membrane protein that is involved in diverse physiological functions. Available radioligands used so far to characterize the I1R were able to bind with similar affinities to 2-adrenergic receptors ( 2-ARs) and to I1R. This feature was a major drawback for an adequate characterization of this receptor subtype. New imidazoline analogs were...