From Agrobacterium tumefaciens, strain B6, a clone B6Ri could be isolated which grows well in presence of 150 ,ug/ml rifampicin. Moreover B6Ri does not alter the rifampicin in the medium (quantity, spectrum in visible light, ability to inhibit the growth of B6). B6Ri is able to induce crown-galls on leaves of Kalanchoe in the presence of 100 /^g/ml rifampicin. Therefore the rifampicin-mediated ...

This study was designed to investigate the effect of different concentrations of rifampicin on osteogenic differentiation and proliferation of mesenchymal stem cells (MSCs) in human bone marrow. Rifampicin treatment at 0, 4, 8, 16, 32, 64, and 128 mg/mL was applied throughout the whole process, from stromal cells purified from human bone marrow to differentiated bone cells. The effect of rifamp...

High-level methicillin-resistant Staphylococcus aureus (MRSA) isolates show rapid evolution of rifampicin resistance, forcing reliance upon expensive and often inferior antibiotics to manage these infections. Accordingly, this study was conducted to: 1) evaluate the level of multidrug resistance among hospital-associated MRSA isolates from Chennai, India; 2) determine their rifampicin resistanc...

BACKGROUND The prevalence of resistance to rifampicin and fusidic acid among Malaysian strains of methicillin-resistant Staphylococcus aureus (MRSA) is increasing. This study aimed to determine the mechanisms of rifampicin and fusidic acid resistance and the genetic diversity of MRSA strains from a Malaysian tertiary hospital. METHODS Minimum inhibitory concentrations (MIC) for 21 MRSA strain...

In Mycobacterium tuberculosis, involvement of alterations of the RNA polymerase beta subunit in resistance to rifampicin has been described by Telenti et al. To determine if the same correlation could be observed between the mutation of the rpoB gene and clinically isolated M. tuberculosis of the rifampicin-resistant phenotype in Japan, 47 strains of M. tuberculosis of the rifampicin-resistant ...

OBJECTIVES To assess plasma steady-state pharmacokinetics (PK) of rifampicin, isoniazid, saquinavir and ritonavir in HIV and tuberculosis (TB) co-infected patients, and investigate potential interactions between TB drugs and protease inhibitors (PIs). METHODS Open-label, single-arm, sequential PK study including 22 patients with HIV infection and TB. During the first 2 months, patients receiv...

Selection and regrowth of variants resistant to 0.016-32 mg/L of rifampicin, which were present at a frequency of 10(-7) in the initial inoculum, were seen when large inocula (> 10(5) cfu/mL) of Staphylococcus epidermidis ATCC 35984 were incubated with the drug. Conventional MIC determinations using approximately 10(5) cfu/mL did not detect the resistant variants. Larger inocula increased the M...

Current treatment for leprosy is based on standard MDT which consists of dapsone, rifampicin, and clofazamine (WHO 1982). However, other antibiotics like ofloxacin, minocycline are also administered to patients, if required. Prior to the introduction of MDT, dapsone monotherapy was used for treatment. Long term monotherapy with dapsone resulted in poor compliance, treatment failures and emergen...

1973) and possibly shock hypotension are responsible for the acute oliguria. This may be mediated by an immune reaction, for patients on an intermittent regimen have high levels of circulating antirifampicin antibody (Aquinas et al., 1972). The patient's husband confinned her history and we believed that it was authentic. She had been taking rifampicin and sodium aminosalicylate regularly for 1...

In order to clarify the biological effects of rifampicin and its derivatives on liver cells, the actions of these antibiotics on the energy transfer reactions were observed in rat liver mitochondria. Rifampicin, 25-desacetyl rifampicin and rifampicin quinone at concentrations of 2.8x10-5-2.7x10-4M had little effect on the respiration and several energy transfer reactions in rat liver mitochondr...