BACKGROUND Late-onset multiple acyl-CoA dehydrogenase deficiency (MADD) is the most common type of lipid storage myopathies in China. Most patients with late-onset MADD are well responsive to riboflavin. Up to now, these patients are often treated with glucocorticoids as the first-line drug because they are misdiagnosed as polymyositis without muscle biopsy or gene analysis. Although glucocorti...

in conjugation as the dietary riboflavin is raised from 0.025 to 0.25 to 2.5 mg/day/kg of body weight. These data were obtained by feeding the test level of vitamin for 7 days prior to administra tion of the carcinogen. Continued feeding of 2.5 mg. of riboflavin for 16 days increased the per centage of conjugation (expressed as conjugated aminofluorene) still further to an average of 51. Riggs ...

Nutritional surveys (food consumption, clinical and biochemichal) were conducted in a small institution for homeless children. Results showed that only 30% of the children presented adequate calorie intake. Most of the children presented adequate protein intake, but almost half consumed less than 2/3 of the calcium RDA considered necessary. Food handling, processing, and distribution also prove...

Treatment of the genetic metabolic myopathies remains generally unsatisfactory with the exception of a select few. Multiple Acyl Co-A Dehydrogenase Deficiency (Glutaric Aciduria type II), in particular, has been shown to respond well to riboflavin supplementation. Recently, studies have also confirmed the effectiveness of recombinant enzyme replacement therapy for Acid Maltase Deficiency (Pompe...

Manipulation of nutritional factors, either by supple mentation or by creation of a deficiency, has already been found to be effective in the therapy of a few specific neoplasms. Particular examples are the Walker 256 carcinoma, which is sensitive to folate deficiency but not to Methotrexate administration; certain lymphoblastic leukemias which are relatively sensitive to asparagine deficiency;...