Liu, Caiqiong, Jianmin Zuo, Evi Pertens, Peter B. Helli, and Luke J. Janssen. Regulation of Rho/ROCK signaling in airway smooth muscle by membrane potential and [Ca ]i. Am J Physiol Lung Cell Mol Physiol 289: L574–L582, 2005. First published June 3, 2005; doi:10.1152/ajplung.00134.2005.—Recently, we have shown that Rho and Rho-activated kinase (ROCK) may become activated by high-millimolar KCl,...

AIMS Chronic myopathy has been described in alcoholics, characterized by atrophy of type II fibres, and vitamin D deficiency. Low serum vitamin D levels are frequent in alcoholics. The possibility exists that serum vitamin D levels are related to muscle changes in a murine experimental model. METHODS Histological analysis of the right gastrocnemius muscle was performed in four groups of adult...

Chang, Shaohua, Joseph A. Hypolite, Michael E. DiSanto, Arun Changolkar, Alan J. Wein, and Samuel Chacko. Increased basal phosphorylation of detrusor smooth muscle myosin in alloxaninduced diabetic rabbit is mediated by upregulation of Rho-kinase and CPI-17. Am J Physiol Renal Physiol 290: F650–F656, 2006. First published October 4, 2005; doi:10.1152/ajprenal.00235.2005.—Urinary bladder dysfunc...

Rho protein regulates transcription termination in E. coli. Some of the temperature-sensitive mutants defective in Rho protein, e.g., ts15, show remarkable pleiotropic phenotypes. The ts mutations map between the ilv and cya loci on the E. coli chromosome. We have cloned the gene that restores the wild-type phenotypes of these mutants. Genetic and biochemical characterizations have shown that t...

Rho and Rac small GTPases associate with type-I phosphatidylinositol 4-phosphate 5-kinase to regulate the production of phosphatidylinositol 4,5-bisphosphate. This lipid appears to mediate some of the effects of Rho and Rac on the actin cytoskeleton. The genes for several type-I phosphatidylinositol 4-phosphate 5-kinases have been cloned recently but it is not known which one interacts with Rho...

Two strand-specific origins of replication appear to be required for mammalian mitochondrial DNA (mtDNA) replication. Structural equivalents of these origins are found in the rep sequences of Saccharomyces cerevisiae mtDNA. These striking similarities have contributed to a universal model for the initiation of mtDNA replication in which a primer is created by cleavage of an origin region transc...

The Rewriting-calculus (Rho-calculus), is a minimal framework embedding Lambdacalculus and Term Rewriting Systems, by allowing abstraction on variables and patterns. The Rho-calculus features higher-order functions (from Lambda-calculus) and pattern-matching (from Term Rewriting Systems). In this paper, we study extensively a second-order Rho-calculus à la Church (RhoF) that enjoys subject redu...

In cite{p}, Park introduced the quadratic $rho$-functional inequalitiesbegin{eqnarray}label{E01}&& |f(x+y)+f(x-y)-2f(x)-2f(y)| \ && qquad le  left|rholeft(2 fleft(frac{x+y}{2}right) + 2 fleft(frac{x-y}{2}right)- f(x) -  f(y)right)right|,  nonumberend{eqnarray}where $rho$ is a fixed complex number with $|rho|

The prospect of using linkage disequilibrium (LD) for fine-scale mapping in humans has attracted considerable attention, and, during the validation of a set of single-nucleotide polymorphisms (SNPs) for linkage analysis, a set of data for 4,833 SNPs in 538 clusters was produced that provides a rich picture of local attributes of LD across the genome. LD estimates may be biased depending on the ...

Five mutant rho proteins, representing alterations at three different locations in the Escherichia coli rho gene that affect ATP hydrolytic activity but not RNA binding, were examined in vivo for function at the rho-dependent IS2 and bacteriophage lambda tR1 terminators. The altered amino acids in rho are located at highly conserved residues near the beta 1 and beta 4 strands of the hydrophobic...