The majority of paired sera and synovial fluids from 21 patients with rheumatoid arthritis produced a rapid chemiluminescent response when incubated with human neutrophils. Synovial fluid gave considerably higher responses than the paired serum specimen. In contrast little or no response was found with paired sera and joint fluid taken from patients with gout, psoriasis, and osteoarthritis and ...

The existence of agglutinating substances reactive with autologous and isologous human gamma globulin (yG) has been recognized for some time. These substances were first found in patients with rheumatoid arthritis and were consequently termed "rheumatoid factor" (RF). It is now clear that rheumatoid factor is not specific for rheumatoid arthritis, but occurs in individuals with a wide variety o...

We studied 30 consecutive female schizophrenics diagnosed on Research Diagnostic Criteria (Spitzer et al 1975) and were age and sex matched with 30 normal healthy females comprising the control group. The relevant blood (hemogram, blood sugar and urea serum proteins etc), urine, stool, chest and skull skiagrams were done to rule out any physical illness in study and control Group. The presence ...

Previous work from this laboratory (Oreskes and Spiera, 1966) as well as that of many other investigators (Bartfeld, 1969) has shown that the anti gamma globulin antibodies, otherwise known as rheumatoid factor (RF), are found in many persons with a wide variety of diseases other than rheumatoid arthritis. Indeed, it appears that a majority of individuals exhibiting RF activity do not have rheu...

Rheumatoid factors (RF) are autoantibodies with specificity for the Fc portion of human IgG. Production of RF is a characteristic feature of rheumatoid arthritis (RA) and is detectable in high titer in about 90% of these patients. In this study, we measured total IgM, IgA, IgMRF and IgARF in serum and synovial fluid of 45 RA patients by ELISA and the results were compared with those obtained b...

The rheumatoid factor group of macroglobulins is a characteristic concomitant of rheumatoid arthritis and can be detected readily in the serum of most rheumatoid patients by a variety of serological techniques employing as reactant either human gamma globulin (Heller, Jacobson, Kolodny, and Kammerer, 1954; Singer and Plotz, 1956; Epstein, Johnson, and Ragan, 1956) or erythrocytes sensitized wit...

We applied nonparametric quantitative trait linkage analysis to two rheumatoid arthritis quantitative phenotypes, IgM rheumatoid factor (RF) and anti-cyclic citrullinated peptide autoantibody titer measurements, using 5700 genome-wide Illumina single-nucleotide polymorphism genotypes on 658 Caucasian North American Rheumatoid Arthritis Consortium families. Peak LOD scores for both quantitative ...