(Acta Obstet Gynecol Scand. 2020;99:399–405) Severe maternal morbidity associated with childbirth has increased in the last 30 years United States. A score to predict risk for would be useful help place high-risk women at better-equipped facilities and also address some confounding factors research. The Obstetric Comorbidity Index (OCI) was developed by Bateman Gangne accomplish these goals, bu...

One significant change in International Financial Reporting Standard (IFRS) 9 Instruments is how firms’ equity financial assets (EFA) are presented. The default EFA presentation at fair value through profit or loss (FVTPL); however, IFRS allows irrevocable of other comprehensive income (FVTOCI). Although FVTOCI the most common for both before and after 9, there a increase use FVTPL post via an ...

BACKGROUND Acute myeloid leukemia (AML) with mutated nucleophosmin (NPM1) has been recognized as a distinct leukemia entity in the 2016 World Health Organization (WHO) classification. The genetic events underlying oncogenesis in NPM1-mutated AML that is characterized by a normal karyotype remain unclear. Inositol polyphosphate 4-phosphatase type II (INPP4B), a new factor in the phosphoinositide...

The IR spectra (1400 cm-' to 160 cm-') of the gases at ambient temperature and the Raman spectra (below 1400 cm-') of the liquids near -196 OC are reported for CF,OF and CF,OCI. All fundamentals are assigned under C, symmetry and the results of a normal coordinate analysis are presented. The assignments of Smardzewski and Fox are adopted with one exception for both CF,OF and CF,OCI: the CF, roc...

objective: attention is an important factor in information processing; obsessive- compulsive disorder (ocd) and generalized anxiety disorder (gad) are two main emotional disorders with a chronic course. this research examined the relationship among attentional control and intrusive thoughts (worry, rumination and obsession) in these disorders. it was hypothesized that attentional control is a c...

BACKGROUND Activated B cell-like subtype of diffuse large B cell lymphoma (ABC-DLBCL) presents aggressive clinical courses and poor prognosis. Targeting key pathways may raise the possibility of improving clinical outcomes. METHODS The synergetic effects were assessed by CCK-8 assay and measured by isobologram analysis. The NVP-Bez235 and lenalidomide cytotoxicity were measured by flow cytome...

Acute myeloid leukemia (AML) cells have high oxidative phosphorylation and mitochondrial mass and low respiratory chain spare reserve capacity. We reasoned that targeting the mitochondrial RNA polymerase (POLRMT), which indirectly controls oxidative phosphorylation, represents a therapeutic strategy for AML. POLRMT-knockdown OCI-AML2 cells exhibited decreased mitochondrial gene expression, decr...

Glypicans are a family of glycosylphosphatidylinositol (GPI)-anchored cell surface heparan sulfate proteoglycans (HSPGs). The glypican family, which currently includes glypican, the developmentally regulated rat intestinal transcript OCI-5, and cerebroglycan, is characterized by a similar core protein size and almost complete conservation of cysteine residues. By RT-PCR using degenerate oligonu...

Despite advancements in cancer therapeutics, acute myeloid leukemia patients over 60 years old have a 5-year survival rate of less than 8%. In an attempt to improve this, epigenetic modifying agents have been combined as therapies in clinical studies. In particular combinations with Decitabine and Vorinostat have had varying degrees of efficacy. This study therefore aimed to understand the unde...