The stereoselectivity of the reversible binding interactions between the Dand L-tryptophan enantiomers and serum albumins of different animal species and fragments of human serum albumin (HSA) was investigated by applying three novel high performance liquid chromatographic (HPLC) arrangements. The separations were performed by means of 1) an achiral (diol-bond), 2) a chiral (bovine serum albumi...

Recently testing of Quantum-dot Cellular Automata (QCA) Circuits has attracted a lot of attention. In this paper, QCA is investigated for testable implementations of reversible logic. To amplify testability in Reversible QCA circuits, a test method regarding to Built In Self Test technique is developed for detecting all simulated defects. A new Reversible QCA MUX 2×1 desig...

Hydrogen sulfide (H2S) plays a crucial signalling role in variety of physiological systems, existing as the hydrosulfide anion (HS−) at pH. Combining potency halogen bonding (XB) for recognition water with coumarin fluorophore incorporation acyclic host structural design, first XB receptors to bind and, more importantly, sense pure reversible chemosensing fashion are demonstrated. The exhibit c...

Under many conditions, biomolecules and nanoparticles associate by means of attractive bonds, due to hydrophobic attraction. Extracting the microscopic association or dissociation rates from experimental data is complicated by the dissociation events and by the sensitivity of the binding force to temperature (T). Here we introduce a theoretical model that combined with light-scattering experime...

A fragment of the starch-binding domain (SBDF) of Aspergillus niger glucoamylase was prepared using recombinant DNA techniques, and its thermal unfolding was investigated by high-sensitivity differential scanning calorimetry (DSC). Thermal unfolding of SBDF was found to be reversible at pH 7 as expected from a DSC study of the whole enzyme molecule [Tanaka A. et al., J. Biochem., 117, 1024-1028...

We assessed the effects of type I antiarrhythmic drugs on the binding of ligands to receptors on voltage-sensitive sodium channels of rat cardiac myocytes. The radioligand was [3H]batrachotoxinin A 20 alpha-benzoate ([3H]BTXB), a toxin that binds to the sodium channel. The 8 drugs tested inhibited [3H]BTXB binding in a dose-dependent fashion with IC50 values from 1.34 microM for O-demethylencai...