نتایج جستجو برای: reverse transcriptase inhibitor

تعداد نتایج: 313286  

Journal: :AIDS research and human retroviruses 2011
Bin Zhao Xiaoxu Han Di Dai Jing Liu Haibo Ding Junjie Xu Zhenxing Chu Tristan Bice Yingying Diao Hong Shang

To elucidate the recent changes in prevalence of HIV-1 primary resistance mutations in men who have sex with men (MSM) in Liaoning province, 217 samples from antiretroviral therapy-naive MSM were collected. For 201 samples, the entire protease gene and 256 amino acids of the reverse transcriptase gene were successfully amplified by reverse transcriptase polymerase chain reaction (RT-PCR) and ne...

2013
S Banerjee S. Ganguly K. K. Sen

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) have, in addition to the nucleoside reverse transcriptase inhibitors (NRTIs) and protease inhibitors (PIs), gained a definitive place in the treatment of HIV-1 infections. The present work deals with computational ligand docking methodology, AutoDock 4.0, based on Lamarckian genetic algorithm for virtual screens of a compound database of ...

Journal: :Journal of molecular graphics & modelling 2003
Paul A Keller Chris Birch Scott P Leach David Tyssen Renate Griffith

In a program to identify new structural entities for the inhibition of the HIV-1 reverse transcriptase (RT) enzyme via database searching, a series of RT pharmacophores were developed. By utilising a novel filtering technique, the National Cancer Institute database of compounds was scanned producing 15 compounds to be screened for activity. A notable inclusion was a series of gossypol derivativ...

Journal: :The Pediatric infectious disease journal 2009
Thanyawee Puthanakit Linda Aurpibul Thira Sirisanthana Virat Sirisanthana

Twenty-six Thai HIV-infected children, aged 2 years or less were prospectively enrolled to receive non-nucleoside reverse transcription inhibitor-based highly active antiretroviral therapy (HAART). Twenty-two children (85%) had World Health Organization clinical stage 3 or 4. The median baseline CD4 cell percentage and plasma HIV RNA were 17% and 5.9 log 10 copies/mL, respectively. The median a...

Journal: :The Pediatric infectious disease journal 2009
Podjanee Jittamala Thanyawee Puthanakit Sukrapee Chaiinseeard Virat Sirisanthana

BACKGROUND Nonnucleoside reverse transcription inhibitor (NNRTI)-based antiretroviral therapy (ART) has been widely used as a first-line regimen for the treatment of HIV. This study aimed to determine the rate and predictors of virologic failure and describe patterns of resistance mutation. METHODS The inclusion criteria were children who were <18 years and receiving NNRTI-based ART. Plasma H...

Journal: :Topics in antiviral medicine 2015
Roy M Gulick

There is general consistency among US and European guidelines regarding the initiation of antiretroviral therapy for HIV-infected individuals. Recent and ongoing trials comparing regimens may lead to reevaluation of initial treatment choices. The choice of antiretroviral regimen will also likely be affected by development, evaluation, and availability of newer drugs. This article reviews curren...

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